Document Detail

Left ventricular function in gestational hypertension: serial echocardiographic study.
MedLine Citation:
PMID:  19763118     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Gestational hypertension (GH) is associated with hemodynamic changes, and alterations of systolic and diastolic left ventricular (LV) function. However, the magnitude and pattern of changes of different parameters of LV function and contractility in this patient population have not been fully clarified.
METHODS: Thirty-five pregnant women with GH underwent three echocardiographic examinations, in second and third trimester of pregnancy, and 1 month after delivery. Twelve normotensive pregnant women served as gestational age-matched controls. Hemodynamic parameters and standard indexes of LV systolic and diastolic function were analyzed. Additionally, we have measured peak systolic velocity of mitral annulus (S'), end-systolic elastance (Ees), and early transmitral to early lengthening velocity of mitral annulus ratio (E/E') as parameters of longitudinal function, contractility, and filling, respectively.
RESULTS: Women with GH had initially higher body weight, blood pressure, and heart rate (P < 0.005, P < 0.0001, and P = 0.011, respectively). Temporal analysis of different echocardiographic parameters revealed increase in wall thickness from baseline to second measurement, with consequential increase in LV mass in women with GH (P = 0.014 for septum, P = 0.010 for posterior wall, and P = 0.09 for LV mass). No significant changes of LV volumes, ejection fraction (EF), transmitral flow parameters, S', Ees, and E/E' were observed throughout the follow-up in both groups (P = nonsignificant for all). Importantly, pattern of changes was similar in both groups for all examined parameters (P = nonsignificant between groups, for all).
CONCLUSIONS: It appears that changes of LV longitudinal function, filling, and contractility during pregnancy are not significant and not influenced by GH.
Alja Vlahović-Stipac; Vera Stankić; Zoran B Popović; Biljana Putniković; Aleksandar N Nesković
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-09-17
Journal Detail:
Title:  American journal of hypertension     Volume:  23     ISSN:  1941-7225     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-17     Completed Date:  2010-03-23     Revised Date:  2011-06-30    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  85-91     Citation Subset:  IM    
Department of Cardiology, Clinical Hospital Center Zemun, Belgrade, Serbia.
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MeSH Terms
Blood Pressure
Body Weight
Coronary Circulation
Follow-Up Studies
Heart Rate
Heart Septum / ultrasonography
Hypertension, Pregnancy-Induced / physiopathology*,  ultrasonography*
Mitral Valve / physiopathology,  ultrasonography
Myocardial Contraction
Postpartum Period
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Time Factors
Ventricular Function, Left*
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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