Document Detail

Left ventricular function and exercise capacity in patients with slow coronary flow.
MedLine Citation:
PMID:  22044729     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Endothelial and microvascular dysfunction have been implicated in slow coronary flow (SCF). How and to what extent do these etiological factors affect left ventricular (LV) function and exercise capacity?
AIM: The aim of the study was to evaluate LV systolic and diastolic function by pulsed tissue Doppler imaging (TDI) in SCF patients and their effects on exercise capacity.
SUBJECTS AND METHODS: Sixty SCF patients and 20 control subjects were included in the study. Echocardiographic examination, treadmill exercise test, and TDI were performed. Isovolumic myocardial acceleration (IVA) and myocardial performance index (MPI) were measured.
RESULTS: TDI mean parameters for systolic and diastolic LV function were significantly impaired in SCF group with decreased Sa, IVA, Ea/Aa, and increased MPI (0.31 ± 0.06 vs. 0.26 ± 0.04, P < 0.01) compared to control. There was significant correlation between thrombolysis in myocardial infarction (TIMI) frame count and TDI mean parameters for LV systolic function (Sa & IVA, r =-0.53, P < 0.01 & r =-0.36, P < 0.05, respectively). Mean TIMI frame count was correlated with MPI and E/Ea. SCF patients had poorer peak exercise capacity than the controls (9.9 ± 1.9 METs vs. 12.7 ± 2.3, P < 0.01) with significant negative correlation with mean TIMI frame count (r =-0.46, P < 0.01).
CONCLUSION: There is impairment of LV systolic and diastolic function in SCF patients with clinical impact on exercise capacity which emphasizes the importance of close follow-up of these patients for risk stratification.
Islam A Elsherbiny
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Publication Detail:
Type:  Journal Article     Date:  2011-11-02
Journal Detail:
Title:  Echocardiography (Mount Kisco, N.Y.)     Volume:  29     ISSN:  1540-8175     ISO Abbreviation:  Echocardiography     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-30     Completed Date:  2012-06-14     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  8511187     Medline TA:  Echocardiography     Country:  United States    
Other Details:
Languages:  eng     Pagination:  158-64     Citation Subset:  IM    
Copyright Information:
© 2011, Wiley Periodicals, Inc.
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MeSH Terms
Blood Flow Velocity
Coronary Angiography
Coronary Circulation*
Echocardiography, Doppler / methods
Exercise Test / methods,  statistics & numerical data
Exercise Tolerance*
Follow-Up Studies
Middle Aged
Observer Variation
Ventricular Dysfunction, Left / physiopathology*,  ultrasonography*

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