| Left ventricular diastolic function and exercise capacity in patients with Chagas cardiomyopathy. | |
| | |
MedLine Citation:
|
PMID: 20412275 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Parameters of diastolic function have been shown to correlate with exercise capacity (EC) in individuals with impaired left ventricular (LV) systolic function. However, the role of LV diastolic function in predicting EC in Chagas cardiomyopathy has not been reported. OBJECTIVES: This study aimed to determine the relationship between LV diastolic parameters assessed by echocardiography and EC in patients with Chagas cardiomyopathy. METHODS: We studied 40 patients (23 men; 49 + or - 8 years), with diagnosis of Chagas disease and dilated cardiomyopathy. Medical therapy was individually adjusted according to standardized guidelines. Methods of acquiring two-dimensional Doppler, tissue Doppler imaging (TDI), and their measurements were described. Exercise testing was performed by a Bruce protocol. Brain natriuretic peptide (BNP) levels were also determined. RESULTS: Most patients (63%) were in NYHA functional class I. Mean peak oxygen consumption estimated (peakVO(2)) was 31.7 + or - 10.2 mL/kg per minute, and mean left ventricular ejection fraction (LVEF) was 36.3 + or - 7.8%. Univariate analysis showed that various echocardiographic parameters of diastolic function were correlated with peakVO(2). There was no correlation between BNP levels or LVEF and EC. Multivariate analysis, after adjustment for age and gender, revealed that E/E' ratio and left atrial volume (LAV), emerged as independent predictors of EC, as demonstrated in the model: peakVO(2)= 60.825 + (0.439 x LAV) - (1.620 x E/E' ratio) - (0.483 x age) - (4.821 x female gender). The R(2) of this model was 0.52. Conclusions: Functional capacity assessed by peakVO(2) was related to increase LV filling pressures, independently on systolic function in patients with Chagas cardiomyopathy. (Echocardiography 2010;27:519-524). |
| | |
Authors:
|
Marcia Maria Oliveira Lima; Maria Carmo P Nunes; Manoel O C Rocha; Francilu Rodrigues Beloti; Maria Clara N Alencar; Antônio Luiz P Ribeiro |
Related Documents
:
|
22429265 - Exercise therapy - the public health message. 17570635 - Mitral valve resistance as a determinant of resting and stress pulmonary artery pressur... 17302715 - Effects of cardiac resynchronization therapy on diastolic function: evaluation by radio... 21445905 - Analysis of a snp linked to lactase persistence: an exercise for teaching molecular bio... 9000155 - Possible mechanisms of central nervous system fatigue during exercise. 7614505 - Comparison of the effects of cilazapril and captopril versus placebo on exercise testin... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-16 |
Journal Detail:
|
Title: Echocardiography (Mount Kisco, N.Y.) Volume: 27 ISSN: 1540-8175 ISO Abbreviation: Echocardiography Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-07-08 Completed Date: 2010-10-29 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8511187 Medline TA: Echocardiography Country: United States |
Other Details:
|
Languages: eng Pagination: 519-24 Citation Subset: IM |
Affiliation:
|
Federal University of Minas Gerais, School of Medicine, Belo Horizonte, MG, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Chagas Cardiomyopathy
/
physiopathology*,
ultrasonography* Diastole Echocardiography / methods* Enzyme-Linked Immunosorbent Assay Exercise Test Female Humans Linear Models Male Middle Aged Natriuretic Peptide, Brain / blood Oxygen Consumption / physiology Statistics, Nonparametric Systole Ventricular Dysfunction, Left / physiopathology*, ultrasonography* |
| Chemical | |
Reg. No./Substance:
|
114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Rosiglitazone, but not pioglitazone, improves myocardial systolic function in type 2 diabetic patien...
Next Document: Importance of Detection of Segmental Wall Motion Abnormalities of Left Ventricle in Nontraumatic Sub...