Document Detail


Left ventricular contraction-relaxation coupling in normal, hypertrophic, and failing myocardium quantified by speckle-tracking global strain and strain rate imaging.
MedLine Citation:
PMID:  20434880     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The aim of this study was to noninvasively quantify global left ventricular (LV) contraction and relaxation, and to investigate their relationship in normal, hypertrophic, and failing myocardium. METHODS: Fifty patients with hypertensive LV hypertrophy (LVH) (LVH group), 50 patients with dilated cardiomyopathy (DCM) (DCM group), and 50 normal subjects (control group) had echocardiographic evaluations. Global LV peak systolic strain (PSS) and peak relaxation rate (PRR) during early diastole were analyzed by speckle-tracking strain and strain rate imaging in the longitudinal and circumferential directions. RESULTS: Both global PSS and PRR were reduced in the LVH group in the longitudinal direction. In the circumferential direction, global PSS was maintained and global PRR was reduced in the LVH group. The reductions in both global PSS and PRR were more pronounced in both directions in the DCM group compared with the other 2 groups. Global PSS correlated strongest with global PRR among the clinical and echocardiographic variables, which exhibited the best fit with exponential regressions in both the longitudinal and circumferential directions in all subjects (longitudinal: y=0.15e(-0.10x), r2=0.75; circumferential: y=0.21e(-0.09x), r2=0.76, P<.01, respectively). Multiple regression analysis indicated that global PSS was the most powerful determinant of global PRR in both longitudinal and circumferential directions. CONCLUSION: Global LV function quantified using speckle-tracking echocardiography revealed strong coupling of LV contraction to relaxation sequentially from normal to failing myocardium, regardless of their heterogeneous pathophysiology. In addition, the extent of myocardial systolic shortening was the most powerful independent contributor of LV relaxation in both the longitudinal and circumferential directions. These results strongly indicate that LV myocardial systolic contraction directly regulates its relaxation.
Authors:
Takeshi Takamura; Kaoru Dohi; Katsuya Onishi; Masaki Tanabe; Emiyo Sugiura; Hiroshi Nakajima; Kazuhide Ichikawa; Mashio Nakamura; Tsutomu Nobori; Masaaki Ito
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  23     ISSN:  1097-6795     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-12     Completed Date:  2010-10-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  747-54     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 American Society of Echocardiography. Published by Mosby, Inc. All rights reserved.
Affiliation:
Mie University Graduate School of Medicine, Tsu, Japan.
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MeSH Terms
Descriptor/Qualifier:
Cardiomyopathy, Hypertrophic / physiopathology*,  ultrasonography
Echocardiography, Doppler, Color / methods*
Elasticity Imaging Techniques / methods*
Female
Follow-Up Studies
Heart Failure / physiopathology*,  ultrasonography
Heart Ventricles / ultrasonography
Humans
Male
Middle Aged
Myocardial Contraction / physiology*
Prognosis
Reproducibility of Results
Sensitivity and Specificity
Stroke Volume / physiology*
Ventricular Dysfunction, Left / physiopathology,  ultrasonography
Ventricular Pressure / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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