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Left Renal Nerves Stimulation Facilitates Ischemia-induced Ventricular Arrhythmia by Increasing Nerve Activity of Left Stellate Ganglion.
MedLine Citation:
PMID:  25066536     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION: Renal sympathetic nerve (RSN) activity plays a key role in systemic sympathetic hyperactivity. Previous studies have shown that cardiac sympathetic hyperactivity, especially the left stellate ganglion (LSG), contributes to the pathogenesis of ventricular arrhythmias (VAs) after acute myocardial infarction (AMI).
METHODS AND RESULTS: Twenty-eight dogs received 3h of continuous left-sided electrical stimulation of RSN (LRS; Group-1, n = 9), sham RSN stimulation (Group-2, n = 9) or LSG ablation plus 3h of LRS (Group-3, n = 10) were included. AMI was induced by ligating the proximal left anterior descending coronary artery. LRS was performed using electrical stimulation on the adventitia of left renal artery at the voltage increasing the systolic blood pressure (BP) by 10%. BP, heart rate variability (HRV), serum norepinephrine (NE) level and LSG function were measured at baseline and the end of each hour of LRS. C-fos and nerve growth factor (NGF) protein expressed in the LSG were examined in Group-1 and Group-2. Compared with baseline, 3h of LRS induced a significant increase in BP, sympathetic indices of HRV, serum NE level and LSG function. The incidence of VAs in Group-1 was significantly higher than other groups. The expression of c-fos and NGF protein in the LSG was significantly higher in Group-1 than Group-2.
CONCLUSION: 3h of LRS induces both systemic and cardiac sympathetic hyperactivity and increases the incidence of ischemia-induced VAs. This article is protected by copyright. All rights reserved.
Authors:
Bing Huang; Lilei Yu; Benjamin J Scherlag; Songyun Wang; Bo He; Kang Yang; Kai Liao; Zhibing Lu; Wenbo He; Ling Zhang; Sunny S Po; Hong Jiang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-28
Journal Detail:
Title:  Journal of cardiovascular electrophysiology     Volume:  -     ISSN:  1540-8167     ISO Abbreviation:  J. Cardiovasc. Electrophysiol.     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9010756     Medline TA:  J Cardiovasc Electrophysiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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