| Left atrial pressure and dominant frequency of atrial fibrillation in humans. | |
| | |
MedLine Citation:
|
PMID: 21034858 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Atrial stretch is thought to play a role in the development of atrial fibrillation (AF). However, the precise mechanism by which stretch contributes to AF maintenance in humans is unknown. OBJECTIVE: The purpose of this study was to determine the impact of left atrial (LA) pressure on AF frequency in patients undergoing catheter ablation of AF. METHODS: The subjects of this study were 58 consecutive patients with persistent AF (n = 40) or paroxysmal AF (n = 18) undergoing LA ablation. LA pressure was measured before ablation. Both atria and the coronary sinus were mapped, and regional dominant frequency (DF) was determined. RESULTS: Mean LA pressure in the persistent AF group was significantly higher than in the paroxysmal AF group (18 ± 5 vs 10 ± 4 mmHg, P <.0001). Mean DF in the persistent AF group was also higher than in the paroxysmal AF group (6.36 ± 0.51 Hz and 5.83 ± 0.54 Hz, P = .0006). In patients with persistent AF, there was a significant correlation between LA pressure and DF at the LA appendage (r = 0.55, P = .0002). DF(max) was found at the LA appendage region in 24 (60%) of the 40 patients with persistent AF (P = .0006). In multivariate analysis, LA pressure was the only independent predictor of DF(max) in the LA appendage (P = .04, odds ratio 1.41, 95% confidence interval 1.02-1.94). CONCLUSION: Higher LA pressure in patients with persistent AF implies that these patients are more vulnerable to stretch-related remodeling than are patients with paroxysmal AF. The DF of AF was directly related to LA pressure in patients with persistent AF. This finding suggests that atrial stretch may contribute to the maintenance of AF in humans by stabilizing high-frequency sources. |
| | |
Authors:
|
Kentaro Yoshida; Magnus Ulfarsson; Hakan Oral; Thomas Crawford; Eric Good; Krit Jongnarangsin; Frank Bogun; Frank Pelosi; Jose Jalife; Fred Morady; Aman Chugh |
Related Documents
:
|
1478218 - Haemodynamic analysis of atrioventricular tachycardia. 2153498 - Effect of atrial natriuretic peptide on blood pressure, guanosine 3':5'-cyclic monophos... 17086538 - B-type natriuretic peptide level in a patient with constrictive pericarditis. 6830668 - Left to right atrial shunting in tricuspid atresia. 9296228 - Noninvasive evaluation of cardiotoxicity of 5-fluorouracil and low doses of folinic aci... 4030608 - Transpulmonary passage of venous air emboli. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-26 |
Journal Detail:
|
Title: Heart rhythm : the official journal of the Heart Rhythm Society Volume: 8 ISSN: 1556-3871 ISO Abbreviation: Heart Rhythm Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-01-31 Completed Date: 2011-06-16 Revised Date: 2012-02-02 |
Medline Journal Info:
|
Nlm Unique ID: 101200317 Medline TA: Heart Rhythm Country: United States |
Other Details:
|
Languages: eng Pagination: 181-7 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Analysis of Variance Atrial Appendage / physiology Atrial Fibrillation / diagnosis, surgery* Atrial Function, Left / physiology* Chi-Square Distribution Cohort Studies Echocardiography / methods Electrocardiography / methods Electrophysiologic Techniques, Cardiac Female Follow-Up Studies Humans Male Middle Aged Pressure* Risk Assessment Severity of Illness Index Tachycardia, Paroxysmal / diagnosis*, therapy Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
|
P01 HL039707-20/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: To the editor--ICD implantation early after myocardial infarction.
Next Document: Multicompartment vectors as novel drug delivery systems: selective activation of T?? lymphocytes aft...