| Left atrial dysfunction in patients with patent foramen ovale and atrial septal aneurysm scheduled for transcatheter closure may play a role in aura genesis. | |
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MedLine Citation:
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PMID: 20624202 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: It has been suggested that a left atrial (LA) dysfunction induced by large shunt and large atrial septal aneurysm (ASA) may act as a concurrent mechanism of arterial embolism in patients with patent foramen ovale (PFO) and prior stroke. We aimed to evaluate the potential contribution of this mechanism as trigger of migraine in patients with PFO. METHODS: From January 2007 to September 2009, we prospectively enrolled subjects with migraine who underwent percutaneous PFO closure. Echocardiographic parameter of LA dysfunction was evaluated: pre- and postoperative values were compared to values of different sex and heart rate matched populations: 30 healthy patients, 21 migraine patients without PFO (MwoPFO), and a group of 25 PFO patients without migraine (PFOwoM). The Migraine Disability Assessment Score (MIDAS) was used to assess the incidence and severity of migraine. RESULTS: Forty-five patients (38 females, mean age 38 +/- 6.7 years, mean MIDAS 35.8 +/- 4.7, and 28 patients with migraine with aura) fulfilled the inclusion criteria. After successful percutaneous closure (mean follow-up of 18.2 +/- 4.8 months), PFO closure remained complete in 95%; 35 of 45 patients reported resolution or amelioration of migraine (mean MIDAS score 12.3 +/- 8.8, P < 0.03). All patients with aura reported aura resolution. Preclosure values demonstrated significantly greater LA dysfunction, when compared with healthy and MwoPFO groups. Among patients in the study group, only patients with migraine with aura showed LA dysfunction comparable to PFOwoM patients. CONCLUSION: This study suggests that LA dysfunction probably does not contribute to migraine itself but may play a role in the genesis of aura symptoms. |
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Authors:
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Gianluca Rigatelli; Fabio Dell'avvocata; Paolo Cardaioli; Federico Ronco; Massimo Giordan; Gabriele Braggion; Silvio Aggio; Mauro Chinaglia; Jack P Cheng; Aravinda Nanjundappa |
Publication Detail:
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Type: Journal Article Date: 2010-07-06 |
Journal Detail:
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Title: Journal of interventional cardiology Volume: 23 ISSN: 1540-8183 ISO Abbreviation: J Interv Cardiol Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-19 Completed Date: 2010-12-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8907826 Medline TA: J Interv Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 370-6 Citation Subset: IM |
Affiliation:
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Section of Adult Congenital and Adult Heart Disease, Cardiovascular Diagnosis and Endoluminal Interventions, Rovigo General Hospital, Rovigo, Italy. jackyheart@libero.it |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Atrial Function, Left / physiology* Case-Control Studies Female Foramen Ovale, Patent / physiopathology*, surgery Heart Aneurysm / physiopathology*, surgery Heart Atria / physiopathology Humans Male Migraine with Aura / physiopathology* Prospective Studies Septal Occluder Device |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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