Document Detail


Leflunomide prevents the development of experimentally induced myasthenia gravis.
MedLine Citation:
PMID:  7672879     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Myasthenia gravis is an autoimmune disease in which autoantibodies specific to the acetylcholine receptor (AChR) are formed, leading to a gradual destruction of the receptors in muscles that are responsible for picking up nerve impulses, and results in weakness and eventual loss of muscle function. The novel immunomodulating drug leflunomide (HWA 486) has been shown to be very effective in preventing and halting ongoing disease in an array of experimental autoimmune disorders and reactions leading to organ graft rejection. Further, recent data from phase II clinical trials indicate that this drug is efficacious and is safe in humans with rheumatoid arthritis. In the studies reported here, we found that rats immunized with AChR-protein and not receiving leflunomide developed experimental myasthenia gravis (EMG) between day 7 and 11 post-immunization, and about 79% of these animals expressed clinical signs of disease. Treatment of AChR-protein immunized rats with leflunomide, from the day of disease induction, totally suppressed the development of EMG. Thus, the results we have obtained using leflunomide in EMG indicate that this drug could be beneficial in combating myasthenia gravis in humans.
Authors:
B Vidic-Dankovic; D Kosec; M Damjanovic; S Apostolski; K Isakovic; R R Bartlett
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of immunopharmacology     Volume:  17     ISSN:  0192-0561     ISO Abbreviation:  Int. J. Immunopharmacol.     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-10-18     Completed Date:  1995-10-18     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7904799     Medline TA:  Int J Immunopharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  273-81     Citation Subset:  IM    
Affiliation:
Immunology Research Center, Belgrade, Serbia Montenegro.
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MeSH Terms
Descriptor/Qualifier:
Animals
Autoantibodies / biosynthesis
Autoimmune Diseases / etiology,  immunology,  prevention & control*
Female
Flow Cytometry
Immunization
Immunosuppressive Agents / pharmacology,  therapeutic use*
Isoxazoles / pharmacology,  therapeutic use*
Myasthenia Gravis / etiology,  immunology,  prevention & control*
Rats
Rats, Inbred Strains
Receptors, Cholinergic / immunology
T-Lymphocyte Subsets / drug effects,  immunology
Thymus Gland / drug effects,  pathology
Time Factors
Torpedo
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Immunosuppressive Agents; 0/Isoxazoles; 0/Receptors, Cholinergic; 75706-12-6/leflunomide

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