Document Detail

Leflunomide-induced polymyositis in a patient with rheumatoid arthritis.
MedLine Citation:
PMID:  19526307     Owner:  NLM     Status:  MEDLINE    
Although rheumatoid arthritis (RA) and myositis are major autoimmune diseases, co-occurrence of the two is rare. We treated a patient who developed polymyositis (PM) following the treatment of RA with leflunomide. Prednisolone (PSL) in combination with methotrexate (MTX) was effective in managing the PM, but the RA relapsed during the treatment. Based on the clinical course, we suspect that the PM was induced by the leflunomide treatment and suggest that clinicians should consider the possibility of this rare adverse event in cases of cholestyramine-resistant elevation of transaminases.
Sae Ochi; Ken Taniguchi; Masakazu Nagashima
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-06-13
Journal Detail:
Title:  Modern rheumatology / the Japan Rheumatism Association     Volume:  19     ISSN:  1439-7595     ISO Abbreviation:  Mod Rheumatol     Publication Date:  2009  
Date Detail:
Created Date:  2009-08-04     Completed Date:  2009-11-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100959226     Medline TA:  Mod Rheumatol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  443-6     Citation Subset:  IM    
Department of Rheumatology, Tokyo Metropolitan Bokutoh Hospital, 4-23-15 Kohtohbashi, Sumida-ku, Tokyo 130-8575, Japan.
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MeSH Terms
Adjuvants, Immunologic / adverse effects*
Alanine Transaminase / blood
Anti-Inflammatory Agents / therapeutic use
Antirheumatic Agents / adverse effects*
Arthritis, Rheumatoid / complications,  drug therapy,  pathology*
Aspartate Aminotransferases / blood
Drug Therapy, Combination
Immunosuppressive Agents / therapeutic use
Isoxazoles / adverse effects*
Methotrexate / therapeutic use
Middle Aged
Muscle, Skeletal / drug effects,  pathology
Polymyositis / chemically induced,  drug therapy,  pathology*
Prednisolone / therapeutic use
Treatment Outcome
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Anti-Inflammatory Agents; 0/Antirheumatic Agents; 0/Immunosuppressive Agents; 0/Isoxazoles; 50-24-8/Prednisolone; 59-05-2/Methotrexate; 75706-12-6/leflunomide; EC Aminotransferases; EC Transaminase

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