| Lectins for gastrointestinal targeting--15 years on. | |
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MedLine Citation:
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PMID: 10721794 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the mid-1980s, the concept of bioadhesion using synthetic polymers emerged, and brought with it the promise of improved efficiency for the delivery of drugs via mucosal surfaces. Studies in the author's laboratory concentrated on 'biological' bioadhesion using the naturally-occurring proteins, lectins, which recognise and bind sugars in glycoconjugates, such as those found on the surfaces of cells. Tomato Lectin (TL) was extensively studied as a putative non-toxic lectin with potential for drug targeting/delivery to the gastrointestinal (GI) tract. In vitro, the TL displayed impressive binding to the intestinal mucosa, but in vivo failed to significantly modify intestinal transit. A number of research groups have coupled the TL to microparticles, and significant systemic uptake of these has been observed in animal studies. Polymers with pendant sugars have also been shown to be bioadhesive, by interacting with endogenous lectins present on the cells of the GI tract. The use of lectins to target to Peyer's patches and diseased tissues in the colon is an interesting development, but much work remains to be done. Lectins also have potential in mucosal vaccines. Before advanced drug delivery systems using lectins can be realised, rigorous evaluation of their toxicity and immunogenicity will be required, but they clearly offer a number of possibilities for GI drug targeting systems in the future. |
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Authors:
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J F Woodley |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of drug targeting Volume: 7 ISSN: 1061-186X ISO Abbreviation: J Drug Target Publication Date: 2000 |
Date Detail:
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Created Date: 2000-05-11 Completed Date: 2000-05-11 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9312476 Medline TA: J Drug Target Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 325-33 Citation Subset: IM |
Affiliation:
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Laboratoire de Cinétique des Xénobiotiques, Faculté des Sciences Pharmaceutiques, Toulouse, France. woodley@cict.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Digestive System / metabolism* Drug Delivery Systems* Humans Lectins / administration & dosage*, immunology, toxicity Peyer's Patches / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Lectins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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