| Lectins can reverse the distal intestinal atrophy associated with elemental diets in mice. | |
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MedLine Citation:
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PMID: 11876719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Elemental diets cause intestinal atrophy and reduced intestinal integrity, which can lead to significant increases in intestinal permeability and bacterial translocation. Recently, several lectins have been shown to have trophic effects on the intestine. AIMS: We examined the effects of concanavalin-A and phytohaemagglutinin on cell proliferation and crypt fission throughout the intestine of mice fed on elemental diets. METHODS: Mice were randomized to chow fed, elemental diet, elemental diet plus concanavalin-A and elemental diet plus phytohaemagglutinin groups. Cell proliferation and crypt fission were estimated in microdissected crypts. Plasma gastrin and enteroglucagon levels were measured by radioimmunoassay. RESULTS: Elemental diet feeding significantly decreased cell proliferation and crypt fission of the middle and distal small intestine and throughout the colon. Phytohaemagglutinin significantly increased the weight of the intestine, but concanavalin-A had little effect. Cell proliferation in the small intestine was significantly increased by both lectins. However, in the stomach and colon, only phytohaemagglutinin increased proliferation. Crypt fission in the colon was dramatically increased by phytohaemagglutinin. Phytohaemagglutinin increased the plasma gastrin level, but not the enteroglucagon level. CONCLUSIONS: Lectins have significant trophic effects on the small intestine and colon of mice fed elemental diets, and these actions vary between different sites in the gastrointestinal tract. |
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Authors:
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M Sasaki; A J Fitzgerald; G Grant; M A Ghatei; N A Wright; R A Goodlad |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Alimentary pharmacology & therapeutics Volume: 16 ISSN: 0269-2813 ISO Abbreviation: Aliment. Pharmacol. Ther. Publication Date: 2002 Mar |
Date Detail:
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Created Date: 2002-03-05 Completed Date: 2002-06-04 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8707234 Medline TA: Aliment Pharmacol Ther Country: England |
Other Details:
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Languages: eng Pagination: 633-42 Citation Subset: IM |
Affiliation:
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Department of Histopathology, Imperial College School of Medicine, Hammersmith Hospital, London, UK. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atrophy / chemically induced*, drug therapy, pathology* Cell Division / drug effects Colon / drug effects, pathology, physiopathology Concanavalin A / pharmacology Food, Formulated / adverse effects* Gastrins / blood Intestine, Small / drug effects*, pathology*, physiopathology Lectins / pharmacology*, therapeutic use Male Metaphase / drug effects Mice Organ Size / drug effects Phaseolus Phytohemagglutinins / pharmacology Plant Lectins Radioimmunoassay Random Allocation Stomach / drug effects, metabolism Weight Gain / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Gastrins; 0/Lectins; 0/Phytohemagglutinins; 0/Plant Lectins; 11028-71-0/Concanavalin A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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