Document Detail


Lectin-like oxidized low-density lipoprotein receptor 1 and matrix metalloproteinase expression in ruptured and unruptured multiple dissections of distal middle cerebral artery: case report.
MedLine Citation:
PMID:  19936607     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Oxidized low-density lipoprotein receptor 1 (LOX1) is a critical factor for atherosclerosis in a variety of vascular diseases; however, its major role in cerebral arterial dissecting aneurysm is unclear.
CLINICAL PRESENTATION: We present a case of remarkable contrast of LOX1 expression in ruptured and unruptured multiple middle cerebral artery dissections and discuss the correlation of LOX1 with matrix metalloproteinases (MMPs). A 59-year-old woman presented with subarachnoid hemorrhage associated with left temporal subcortical hematoma. Emergent cerebral angiography demonstrated aneurysmal dilatation at the origin of the left anterior temporal artery (ATA) and occlusion on the distal side of ATA. Infectious aneurysm was excluded. Intraoperative findings showed ruptured dissection of the left ATA and unruptured aneurysmal dilatation of another temporal branch of the left M1 portion. Both lesions were trapped by clips and resected. Histopathological examination confirmed that both ruptured and unruptured aneurysmal dilatations were diagnosed as arterial dissections. Immunohistochemical examination demonstrated remarkable expressions of LOX1, MMP-2, and MMP-9 in hypertrophic media outside the intima in ruptured dissection, on the other hand, those expressions in the intima and inside hypertrophic media in the unruptured dissection.
CONCLUSIONS: This is the first report to reveal immunohistochemical findings of LOX1 and MMPs in multiple dissections of MCA. The contrast localization of LOX1 and MMPs might contribute to the fragility of the arterial wall layer of ruptured/unruptured arterial dissections.
Authors:
Atsushi Saito; Miki Fujimura; Takashi Inoue; Hiroaki Shimizu; Teiji Tominaga
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-11-20
Journal Detail:
Title:  Acta neurochirurgica     Volume:  152     ISSN:  0942-0940     ISO Abbreviation:  Acta Neurochir (Wien)     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-18     Completed Date:  2011-01-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151000     Medline TA:  Acta Neurochir (Wien)     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  1235-40     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Graduate School of Medicine, Tohoku University, 1-1 Seiryomachi, Aoba, Sendai, Miyagi, 980-8574, Japan. satsushi2002@yahoo.co.jp
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MeSH Terms
Descriptor/Qualifier:
Cerebral Angiography
Female
Humans
Intracranial Aneurysm / enzymology,  metabolism*,  pathology
Matrix Metalloproteinase 2 / biosynthesis
Matrix Metalloproteinase 9 / biosynthesis
Matrix Metalloproteinases / metabolism*
Middle Aged
Middle Cerebral Artery / enzymology,  metabolism*,  pathology
Oxidative Stress / physiology
Scavenger Receptors, Class E / metabolism*
Subarachnoid Hemorrhage / enzymology,  metabolism*,  pathology
Chemical
Reg. No./Substance:
0/Scavenger Receptors, Class E; EC 3.4.24.-/Matrix Metalloproteinases; EC 3.4.24.24/Matrix Metalloproteinase 2; EC 3.4.24.35/Matrix Metalloproteinase 9

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