| Lectin histochemistry of normal bronchopulmonary tissues and common forms of bronchogenic carcinoma. | |
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MedLine Citation:
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PMID: 2334254 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Normal bronchopulmonary tissues, areas of basal cell hyperplasia and of squamous metaplasia, and 26 pulmonary carcinomas, including the three major types (squamous cell carcinoma, adenocarcinoma, and oat cell carcinoma), were studied with 12 biotinylated plant lectins. The study demonstrated a rather characteristic lectin-binding profile for most normal epithelial cell types, while pulmonary tumors showed a variation in the lectin reactivity when compared with the whole spectrum of normal cells, with binding of some lectins that were not reactive with normal tissues and a loss of reactivity with others that bound to normal tissues. Adenocarcinomas showed the highest density of reacting sites, while undifferentiated carcinomas were the less-reacting variant. Areas of metaplasia and hyperplasia showed some variation in the lectin-binding profile with normal tissues, but as a whole, there was a much smaller number of reacting sites than tumors. |
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Authors:
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E Alvarez-Fernandez; L Carretero-Albiñana |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of pathology & laboratory medicine Volume: 114 ISSN: 0003-9985 ISO Abbreviation: Arch. Pathol. Lab. Med. Publication Date: 1990 May |
Date Detail:
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Created Date: 1990-06-01 Completed Date: 1990-06-01 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7607091 Medline TA: Arch Pathol Lab Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 475-81 Citation Subset: AIM; IM |
Affiliation:
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Department of Anatomical Pathology, Universidad Complutense, Madrid, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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metabolism Bronchi / metabolism*, pathology Bronchial Neoplasms / metabolism* Carcinoma / metabolism Carcinoma, Bronchogenic / metabolism* Epithelium / metabolism Histocytochemistry Humans Hyperplasia Lectins / diagnostic use* Lung / metabolism*, pathology Lung Neoplasms / metabolism Metaplasia Pulmonary Alveoli / metabolism Reference Values Submucous Plexus / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Lectins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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