| Lecithinized copper, zinc-superoxide dismutase ameliorates ischemia-induced myocardial damage. | |
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MedLine Citation:
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PMID: 11488406 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have reported that lecithin-conjugated recombinant human Cu, Zn-superoxide dismutase (lecithinized SOD) has greater pharmacological potency than unmodified SOD through an increase in cell membrane affinity and half-life in plasma. Recently, ischemia or hypoxia alone has been suggested to result in increased superoxide anions, which lead to apoptosis in cardiomyocytes. We tested the effect of lecithinized SOD in reducing the infarct size following prolonged myocardial ischemia without reperfusion. Rats were subjected to a 24-h left coronary occlusion. Lecithinized SOD, unmodified SOD, free lecithin derivative or PBS was administered intravenously 30 min before coronary occlusion. SOD concentration of the heart, measured by ELISA, was higher in the lecithinized SOD-treated group than in the other groups 24 h after administration. The infarct area ratio of the heart, assessed by TTC staining, in the lecithinized SOD-treated group was significantly smaller than those of the other groups. Both TUNEL-positive cardiomyocytes and DNA laddering were attenuated in the ischemic area of the heart treated with lecithinized SOD. Single bolus administration of lecithinized SOD had a cardioprotective effect against ischemia without reperfusion in the rat model of acute myocardial infarction, possibly due to its sustained high tissue concentration. |
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Authors:
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H Nakajima; M Hangaishi; N Ishizaka; J Taguchi; R Igarashi; Y Mizushima; R Nagai; M Ohno |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Life sciences Volume: 69 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 2001 Jul |
Date Detail:
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Created Date: 2001-08-07 Completed Date: 2001-08-23 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: England |
Other Details:
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Languages: eng Pagination: 935-44 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Medicine, University of Tokyo, Graduate School of Medicine, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals DNA / chemistry Female Heart / drug effects Hemodynamics In Situ Nick-End Labeling Myocardial Infarction / pathology* Myocardium / pathology* Phosphatidylcholines Rats Rats, Sprague-Dawley Superoxide Dismutase / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Phosphatidylcholines; 9007-49-2/DNA; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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