| Lecithin:cholesterol acyltransferase, high-density lipoproteins, and atheroprotection in humans. | |
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MedLine Citation:
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PMID: 20656215 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The lecithin:cholesterol acyltransferase (LCAT) enzyme is responsible for the synthesis of cholesteryl esters in human plasma. Lecithin:cholesterol acyltransferase is a critical enzyme in high-density lipoprotein (HDL) metabolism, and deficiency of LCAT-mediated cholesterol esterification leads to defective HDL maturation with accumulation of nascent pre-beta HDL. In addition to its function in HDL metabolism, LCAT has also long been believed to play a critical role in macrophage reverse cholesterol transport (RCT). However, recent findings have shown that human LCAT overexpression in mice does not enhance macrophage RCT in vivo, and conversely, LCAT-deficient mice display a preserved macrophage RCT despite the severe plasma HDL reduction. In agreement with this observation, defective LCAT activity does not result in enhanced atherosclerosis, despite the reduced HDL cholesterol levels. These findings challenge the notion that LCAT is required for effective atheroprotection and suggest that elevating LCAT expression and/or activity is not a promising therapeutic strategy to reduce cardiovascular risk. |
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Authors:
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Laura Calabresi; Guido Franceschini |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Trends in cardiovascular medicine Volume: 20 ISSN: 1873-2615 ISO Abbreviation: Trends Cardiovasc. Med. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-07-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9108337 Medline TA: Trends Cardiovasc Med Country: United States |
Other Details:
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Languages: eng Pagination: 50-3 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Center E. Grossi Paoletti, Department of Pharmacological Sciences, Università degli Studi di Milano, 20133 Milano, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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