Document Detail

Lecithin changes in murine Mycoplasma pulmonis respiratory infection.
MedLine Citation:
PMID:  582313     Owner:  NLM     Status:  MEDLINE    
We examined the lipid content of bronchoalveolar (BA) washes from both mice and rats infected with Mycoplasma pulmonis, an etiological agent of murine pneumonia. During a 30-day period after intranasal inoculation, the total lipid content from infected and control rats (in milligrams per animal) remained relatively equal and unchanged. The saturated, unsaturated, and total lecithin contents in infected rats (in milligrams per animal) all increased. The maximum lecithin values were detected at 7 to 10 days after infection; later, the levels fell to control values. There was essentially no change in any lecithin value from uninfected animals. Although in BA washes from infected animals the mass of disaturated lecithins increased, the percentage of this fraction in the total lecithin pool decreased. The fatty acids of the lecithins from BA washes of infected mice had significantly less palmitic and significantly more oleic and linoleic acids than the lecithins isolated from the BA washes of control animals. Both the relative decrease in the mass of disaturated lecithins in the BA washes and the increase in the percentage of esterified unsaturated fatty acids in the lecithins may be directly related to the reduced lung function reported to occur during the course of murine M. pulmonis pneumonia.
J D Pollack; H S Weiss; N L Somerson
Related Documents :
14577663 - Pharmacological modulation of fatty acid desaturation and of cholesterol biosynthesis i...
6665743 - Mevalonate supplementation in pregnant rats suppresses the teratogenicity of mevinolini...
22691933 - Antioxidant activities and total phenolic content of aqueous extract of pleurotus ostre...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Infection and immunity     Volume:  24     ISSN:  0019-9567     ISO Abbreviation:  Infect. Immun.     Publication Date:  1979 Apr 
Date Detail:
Created Date:  1979-09-17     Completed Date:  1979-09-17     Revised Date:  2010-09-02    
Medline Journal Info:
Nlm Unique ID:  0246127     Medline TA:  Infect Immun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  94-101     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Fatty Acids / physiology
Fatty Acids, Unsaturated / physiology
Germ-Free Life
Lung Compliance
Mycoplasma Infections / physiopathology*
Pulmonary Surfactants / physiology*
Reg. No./Substance:
0/Fatty Acids; 0/Fatty Acids, Unsaturated; 0/Pulmonary Surfactants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Lymphoreticular disorders of the gastrointestinal tract: roentgenographic features.
Next Document:  Dermatitis herpetiformis and thyrotoxicosis.