| Learning sentinel node biopsy: results of a prospective randomized trial of two techniques. | |
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MedLine Citation:
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PMID: 10520920 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Evidence indicates that sentinel node (SN) biopsy can accurately predict axillary nodal status. Debate exists as to the optimal method of SN identification. METHODS: Patients with clinical T1 or T2 tumors and negative axillae were randomized to SN localization with blue dye (B) alone (n = 50) or blue dye plus radioactivity (B+R) (n = 42). Patients undergoing needle localization (n = 47) were assigned to blue dye. RESULTS: The SN was identified in 110 patients (79%) and contained metastases in 28. The SN predicted the axillary nodal status in 96% of cases. The SN identification rate did not differ between B (88%) or B+R (86%) but was significantly lower in patients requiring localization (64%). The time to SN identification also did not differ between B and B+R. The number of cases done by an individual surgeon was a significant predictor of SN identification. A stepwise logistic regression analysis of factors influencing the success of SN identification identified tumor location, needle localization, number of operations, and body mass index as significant predictors. CONCLUSIONS: Our study does not identify any advantage for the use of the more expensive and complex method of SN identification using B+R compared with B alone, even for surgeons learning the techniques. |
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Authors:
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M Morrow; A W Rademaker; K P Bethke; M S Talamonti; L G Dawes; J Clauson; N Hansen |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Surgery Volume: 126 ISSN: 0039-6060 ISO Abbreviation: Surgery Publication Date: 1999 Oct |
Date Detail:
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Created Date: 1999-10-25 Completed Date: 1999-10-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0417347 Medline TA: Surgery Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 714-20; discussion 720-2 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, and the Lynn Sage Comprehensive Breast Center, Northwestern University Medical School, Chicago, Ill, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Axilla Biopsy / methods* Breast Neoplasms / pathology*, radionuclide imaging* Coloring Agents / diagnostic use Education, Medical, Continuing* Female Humans Logistic Models Lymph Nodes / pathology* Medical Staff, Hospital / education Middle Aged Palpation Prospective Studies Radiopharmaceuticals / diagnostic use Technetium Tc 99m Sulfur Colloid / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Coloring Agents; 0/Radiopharmaceuticals; 0/Technetium Tc 99m Sulfur Colloid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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