Document Detail


Learning-related coordination of striatal and hippocampal theta rhythms during acquisition of a procedural maze task.
MedLine Citation:
PMID:  17372196     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The striatum and hippocampus are conventionally viewed as complementary learning and memory systems, with the hippocampus specialized for fact-based episodic memory and the striatum for procedural learning and memory. Here we directly tested whether these two systems exhibit independent or coordinated activity patterns during procedural learning. We trained rats on a conditional T-maze task requiring navigational and cue-based associative learning. We recorded local field potential (LFP) activity with tetrodes chronically implanted in the caudoputamen and the CA1 field of the dorsal hippocampus during 6-25 days of training. We show that simultaneously recorded striatal and hippocampal theta rhythms are modulated differently as the rats learned to perform the T-maze task but nevertheless become highly coherent during the choice period of the maze runs in rats that successfully learned the task. Moreover, in the rats that acquired the task, the phase of the striatal-hippocampal theta coherence was modified toward a consistent antiphase relationship, and these changes occurred in proportion to the levels of learning achieved. We suggest that rhythmic oscillations, including theta-band activity, could influence not only neural processing in cortico-basal ganglia circuits but also dynamic interactions between basal ganglia-based and hippocampus-based forebrain circuits during the acquisition and performance of learned behaviors. Experience-dependent changes in coordination of oscillatory activity across brain structures thus may parallel the well known plasticity of spike activity that occurs as a function of experience.
Authors:
William E DeCoteau; Catherine Thorn; Daniel J Gibson; Richard Courtemanche; Partha Mitra; Yasuo Kubota; Ann M Graybiel
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-03-19
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  104     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-28     Completed Date:  2007-05-14     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5644-9     Citation Subset:  IM    
Affiliation:
Department of Psychology, St. Lawrence University, Canton, NY 13617, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Corpus Striatum / anatomy & histology*,  physiology
Gene Expression Regulation
Hippocampus / anatomy & histology*,  physiology
Learning*
Male
Maze Learning*
Memory
Nervous System Physiological Phenomena
Oscillometry
Rats
Rats, Sprague-Dawley
Software
Space Perception
Theta Rhythm*
Grant Support
ID/Acronym/Agency:
MH071744/MH/NIMH NIH HHS; MH60379/MH/NIMH NIH HHS
Comments/Corrections

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