Document Detail

Learning enhances adult neurogenesis in the hippocampal formation.
MedLine Citation:
PMID:  10195219     Owner:  NLM     Status:  MEDLINE    
Thousands of hippocampal neurons are born in adulthood, suggesting that new cells could be important for hippocampal function. To determine whether hippocampus-dependent learning affects adult-generated neurons, we examined the fate of new cells labeled with the thymidine analog bromodeoxyuridine following specific behavioral tasks. Here we report that the number of adult-generated neurons doubles in the rat dentate gyrus in response to training on associative learning tasks that require the hippocampus. In contrast, training on associative learning tasks that do not require the hippocampus did not alter the number of new cells. These findings indicate that adult-generated hippocampal neurons are specifically affected by, and potentially involved in, associative memory formation.
E Gould; A Beylin; P Tanapat; A Reeves; T J Shors
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Nature neuroscience     Volume:  2     ISSN:  1097-6256     ISO Abbreviation:  Nat. Neurosci.     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-04-21     Completed Date:  1999-04-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9809671     Medline TA:  Nat Neurosci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  260-5     Citation Subset:  IM    
Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA.
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MeSH Terms
Association Learning / physiology
Blinking / physiology
Cell Division / physiology
Conditioning, Classical / physiology
Dentate Gyrus / cytology*,  physiology*
Learning / physiology*
Maze Learning / physiology
Neurons / cytology
Physical Conditioning, Animal / physiology
Rats, Sprague-Dawley
Grant Support
Comment In:
Nat Neurosci. 1999 Mar;2(3):203-5   [PMID:  10195209 ]

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