Document Detail


Learning enhances adult neurogenesis in the hippocampal formation.
MedLine Citation:
PMID:  10195219     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thousands of hippocampal neurons are born in adulthood, suggesting that new cells could be important for hippocampal function. To determine whether hippocampus-dependent learning affects adult-generated neurons, we examined the fate of new cells labeled with the thymidine analog bromodeoxyuridine following specific behavioral tasks. Here we report that the number of adult-generated neurons doubles in the rat dentate gyrus in response to training on associative learning tasks that require the hippocampus. In contrast, training on associative learning tasks that do not require the hippocampus did not alter the number of new cells. These findings indicate that adult-generated hippocampal neurons are specifically affected by, and potentially involved in, associative memory formation.
Authors:
E Gould; A Beylin; P Tanapat; A Reeves; T J Shors
Related Documents :
15232109 - Sites of neocortical reorganization critical for remote spatial memory.
16040709 - Independent codes for spatial and episodic memory in hippocampal neuronal ensembles.
6439229 - On the role of hippocampal connections in the performance of place and cue tasks: compa...
8309629 - Activation of the human hippocampal formation during auditory-verbal long-term memory f...
23866079 - Hear today, not gone tomorrow? an exploratory longitudinal study of auditory verbal hal...
15912579 - Hippocampal memory modification induced by pattern completion and spike-timing dependen...
18035429 - Neural correlates to both emotion and cognitive functions in the monkey amygdala.
12015239 - Molecular bases of long-term memories: a question of persistence.
20018709 - Performance level modulates adult age differences in brain activation during spatial wo...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Nature neuroscience     Volume:  2     ISSN:  1097-6256     ISO Abbreviation:  Nat. Neurosci.     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-04-21     Completed Date:  1999-04-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9809671     Medline TA:  Nat Neurosci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  260-5     Citation Subset:  IM    
Affiliation:
Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Association Learning / physiology
Blinking / physiology
Cell Division / physiology
Conditioning, Classical / physiology
Cues
Dentate Gyrus / cytology*,  physiology*
Learning / physiology*
Male
Maze Learning / physiology
Neurons / cytology
Physical Conditioning, Animal / physiology
Rats
Rats, Sprague-Dawley
Grant Support
ID/Acronym/Agency:
MH52423/MH/NIMH NIH HHS; MH59970/MH/NIMH NIH HHS
Comments/Corrections
Comment In:
Nat Neurosci. 1999 Mar;2(3):203-5   [PMID:  10195209 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Neuronal growth cone collapse triggers lateral extensions along trailing axons.
Next Document:  Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus.