Document Detail

Learning curve in ultrasonographic screening for selected fetal structural anomalies in early pregnancy.
MedLine Citation:
PMID:  12576250     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the value of first trimester screening by ultrasonography in detecting structural anomalies of the fetus in a general obstetric population. METHODS: During 1993-1998, 20,465 consecutive pregnant women who resided in a defined geographic area participated in ultrasonographic screening for major malformations. These included anomalies of the central nervous system, urinary tract, abdominal wall, and long bones. Heart anomalies were not expected to be detected. The examinations were offered at 13-14 weeks' gestation as part of routine maternal care and were done by specially trained midwives. The pregnancy outcomes were ascertained from obstetric and pediatric records, and the data were completed by information from the national birth and malformation registries. RESULTS: A total of 307 fetuses (1.5%) with a major malformation were found; 67 fetuses (0.3%) had noncardiac major structural defects expected to be detectable by ultrasonography in early pregnancy. Thirty-five of 67 (52%) were identified at the early scan. Sensitivity for these defects increased from 22% to 79% from the first to the last (sixth) study year (P =.009). CONCLUSION: In a low-risk population, adequate sensitivity in screening for major malformations by early ultrasonography can be achieved after a learning curve of 3-4 years.
Pekka Taipale; Martti Ammälä; Riitta Salonen; Vilho Hiilesmaa
Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  101     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-02-10     Completed Date:  2003-03-12     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  273-8     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, HUCH, Jorvi Hospital, Espoo, Finland.
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MeSH Terms
Confidence Intervals
Congenital Abnormalities / epidemiology,  ultrasonography*
Fetal Diseases / ultrasonography*
Fetus / abnormalities*
Gestational Age
Mass Screening / statistics & numerical data
Maternal Age
Middle Aged
Pregnancy Outcome*
Pregnancy Trimester, First
Pregnancy Trimester, Second
Prenatal Care / methods
Risk Assessment
Sensitivity and Specificity
Ultrasonography, Prenatal / methods*,  statistics & numerical data

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