| Learning Stimulus Intervals-Adaptive Timing of Conditioned Purkinje Cell Responses. | |
| | |
MedLine Citation:
|
PMID: 21416378 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Classical conditioning of motor responses, such as the eyeblink response, is an experimental model of associative learning and of adaptive timing of movements. A conditioned blink will have its maximum amplitude near the expected onset of the unconditioned blink-eliciting stimulus and it adapts to changes in the interval between the conditioned and unconditioned stimuli. Previous studies have shown that an eyeblink conditioning protocol can make cerebellar Purkinje cells learn to pause in response to the conditioned stimulus. According to the cerebellar cortical conditioning model, this conditioned Purkinje cell response drives the overt blink. If so, the model predicts that the temporal properties of the Purkinje cell response reflect the overt behaviour. To test this prediction, in vivo recordings of Purkinje cell activity were performed in decerebrate ferrets during conditioning, using direct stimulation of cerebellar mossy and climbing fibre afferents as conditioned and unconditioned stimuli. The results show that Purkinje cells not only develop a change in responsiveness to the conditioned stimulus. They also learn a particular temporal response profile where the timing, not only of onset and maximum but also of offset, is determined by the temporal interval between the conditioned and unconditioned stimuli. |
| | |
Authors:
|
Dan-Anders Jirenhed; Germund Hesslow |
Related Documents
:
|
16298768 - Differential responses of the photoperiodic clock in two passerine birds possessing a s... 578408 - Receptor maturation and synaptogenesis in the golden hamster cochlea. 9378508 - Photoperiodism in higher vertebrates: an adaptive strategy in temporal environment. 15339018 - Monochromatic light stimuli during embryogenesis enhance embryo development and posthat... 1562188 - Behavioral responses in bacteria. 8935038 - The ground rules for arch wire design. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-18 |
Journal Detail:
|
Title: Cerebellum (London, England) Volume: - ISSN: 1473-4230 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-18 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101089443 Medline TA: Cerebellum Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Experimental Medical Science, Lund University, BMC F10, 22184, Lund, Sweden, jirenhed@stanford.edu. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Optimal estimator models for spatial orientation and vestibular nystagmus.
Next Document: The prevention of neural complications in the surgical treatment of scoliosis: the role of the neuro...