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Lean Body Mass Is Better Than Body Surface Area in Correcting GFR.
MedLine Citation:
PMID:  22996236     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: The Gates-based renography (gGFR) and plasma-based clearance rate (pGFR) are conventionally corrected with body surface area (BSA). Limited studies indicated that the lean body mass (LBM) might be better than BSA in correcting pGFR. Therefore, we suggest that LBM is also better in correcting gGFR and improve the correlation coefficient between gGFR and pGFR. METHOD: During June 2009 and December 2010, the gGFR and pGFR of 63 patients with hydronephrosis were measured and corrected with BSA and LBM, respectively. The correlation and regression analyses were conducted to illustrate the power of BSA and LBM correction. RESULTS: In a paired t test, there was no significant difference between pGFR and gGFR in patients with stages 1 and 2, although this was significant in stages 3 and 4. However, neither LBM nor BSA correction could eliminate the difference. In all patients (N = 63), the correlation coefficient (r) between pGFR and gGFR was 0.794 (P < 0.001). After the BSA and LBM correction, r was improved to 0.809 and 0.828, respectively. In all patients, the regression line of pGFRLBM - gGFRLBM was nearer to the original point and its slope closer to 1 than pGFRBSA - gGFRBSA and pGFR - gGFR. Similar results were found in the analysis of most stages and subgroups. CONCLUSIONS: The commonsense of BSA correction should be seriously reevaluated. Lean body mass can better improve the correlation coefficient between paired GFRs than BSA can and it can be suitable in the correction.
Authors:
Hongwei Si; Zhili Lei; Sijin Li; Jianzhong Liu; Jianhua Geng; Shengzu Chen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-19
Journal Detail:
Title:  Clinical nuclear medicine     Volume:  -     ISSN:  1536-0229     ISO Abbreviation:  Clin Nucl Med     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7611109     Medline TA:  Clin Nucl Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
From the *Department of Nuclear Medicine, the First Affiliated Hospital of Shanxi Medical University, Taiyuan, Shanxi Province; and †Department of Nuclear Medicine, Cancer Hospital, Peking Union Medical College, Beijing, China.
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