Document Detail

Leakage of dl-propranolol from cerebrospinal fluid to the bloodstream in the rabbit.
MedLine Citation:
PMID:  886469     Owner:  NLM     Status:  MEDLINE    
Intracerebroventricular (i.c.v.) injection of 500 microgram of dl-propranolol in the conscious rabbit in a rise in mean arterial pressure followed by a small but significant fall (3.2 +/- 1.4 mm Hg between 2 and 4 hours after injection), as has been observed by others. The same dose injected i.v. resulted in a lowering of mean arterial pressure of 6.0 +/- 2.4 mm Hg between 2 and 4 hours after injection. After i.c.v. injection there was a rapid rise in plasma propranolol concentration. Ten minutes after i.c.v. injection the concentration of 80% of the level reached after giving the same dose i.v. After i.c.v. injection there was significant blockade of cardiac beta adrenoreceptors for at least 2 hours. This blockade was determined from the degree of attenuation of isoproterenol-induced tachycardia in rabbits subjected to presynaptic sympathetic nerve block with guanethidine and to vagal block with methscopolamine. Because of the rapid leakage of propranolol from cerebrospinal fluid to plasma it is not possible by means of the technique of i.c.v. injection of the drug to differentiate between central nervous and systemic mechanisms contributing to the lowering of blood pressure.
W P Anderson; P I Korner; A Bobik; J P Chalmers
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pharmacology and experimental therapeutics     Volume:  202     ISSN:  0022-3565     ISO Abbreviation:  J. Pharmacol. Exp. Ther.     Publication Date:  1977 Aug 
Date Detail:
Created Date:  1977-09-22     Completed Date:  1977-09-22     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0376362     Medline TA:  J Pharmacol Exp Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  320-5     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Heart Rate / drug effects
Injections, Intravenous
Injections, Intraventricular
Isoproterenol / antagonists & inhibitors,  pharmacology
Propranolol / administration & dosage*,  blood,  cerebrospinal fluid*,  pharmacology
Time Factors
Reg. No./Substance:
525-66-6/Propranolol; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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