| Lead poisoning in an adult: lead mobilization by pregnancy? | |
| | |
MedLine Citation:
|
PMID: 17562116 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We report a case of acute lead poisoning in an adult female who had last been exposed to lead 7 years ago. She presented with abdominal pain, knee pain, and neurological symptoms, hypertension, chronic kidney disease, and anemia with basophilic stippling and lead gum lines. Compared to during her recent pregnancy, her lead level had almost tripled in 5 months to 81 mcg/dL. Chelation therapy was initiated and improved the patient's symptoms and lead level significantly. In the absence of any new lead exposure or other reasons for increased bone turnover, this acute lead increase was likely due to skeletal mobilization caused by increased resorption from mineralized tissue during and after her pregnancy. This case report illustrates the seriousness of long-term health effects associated with lead poisoning at a multi-organ level, even years after the initial exposure. Thus, patient care should not be limited to the acute treatment of increased lead levels, but also include prevention of increased mobilization and bone turnover and appropriate patient education. In this context, we review various aspects of lead toxicity, especially during pregnancy and lactation. |
| | |
Authors:
|
Matthias L Riess; Josiah K Halm |
Related Documents
:
|
12562956 - Enhanced nitric oxide activity offsets peripheral vasoconstriction during acute hypoxae... 17558066 - Effect of liver disease on maternal and fetal outcome--a prospective study. 23269486 - Structure and steroidogenesis of the placenta in the antarctic minke whale (balaenopter... 23319196 - Alcohol-induced changes in the developing cerebellum. ultrastructural and quantitative ... 22067786 - Can women accurately assess the outcome of medical abortion based on symptoms alone? 8194106 - Three-dimensional dynamics of pseudopod formation and the regulation of turning during ... |
Publication Detail:
|
Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-06-12 |
Journal Detail:
|
Title: Journal of general internal medicine Volume: 22 ISSN: 1525-1497 ISO Abbreviation: J Gen Intern Med Publication Date: 2007 Aug |
Date Detail:
|
Created Date: 2007-07-09 Completed Date: 2007-08-03 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 8605834 Medline TA: J Gen Intern Med Country: United States |
Other Details:
|
Languages: eng Pagination: 1212-5 Citation Subset: IM |
Affiliation:
|
Department of Anesthesiology, Medical College of Wisconsin, MEB 4250, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA. mriess@mcw.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Chelating Agents / therapeutic use Environmental Exposure Female Humans Lead / pharmacokinetics* Lead Poisoning / diagnosis, metabolism*, therapy Pregnancy Pregnancy Complications / metabolism* Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Chelating Agents; 7439-92-1/Lead |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Neoadjuvant chemotherapy followed by radical surgery in patients affected by FIGO stage IVA cervical...
Next Document: The durability of laparoscopic Nissen fundoplication: 11-year outcomes.