Document Detail

Lead and other metals in gestational hypertension.
MedLine Citation:
PMID:  14511869     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To identify any effects that lead, calcium, magnesium, and zinc may have on the development of gestational hypertension. METHODS: Third-trimester 110 normotensive and 33 gestational hypertension cases were assayed for various metal levels, using standard techniques, including atomic absorption spectrometry. RESULTS: Gestational hypertension cases showed significantly higher blood lead levels than normotensives. No differences were noticed regarding calcium (ionized and total), magnesium, and zinc levels. Blood lead was significantly related with blood pressure, even after correcting for the body mass indices and age. Blood pressure levels showed no relation to the other analyzed metals. However, the lead:ionized calcium ratio showed a stronger association with blood pressure, than lead alone. Blood lead showed a significant negative relationship with ionized calcium, but none with the other metals. CONCLUSIONS: Blood lead evidently influenced blood pressure increments and gestational hypertension development. This implies that all efforts should be made to reduce the population's exposure.
J Magri; M Sammut; C Savona-Ventura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  83     ISSN:  0020-7292     ISO Abbreviation:  Int J Gynaecol Obstet     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-09-26     Completed Date:  2004-04-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  29-36     Citation Subset:  IM    
Toxicology Unit, Department of Pathology, St. Luke's Hospital, Gwardamangia, Malta.
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MeSH Terms
Calcium / administration & dosage,  blood
Case-Control Studies
Cross-Sectional Studies
Dietary Supplements / analysis
Hypertension / blood*
Lead / blood*
Magnesium / administration & dosage,  blood
Pregnancy Complications, Cardiovascular / blood*
Pregnancy Trimester, Third
Zinc / administration & dosage,  blood
Reg. No./Substance:
7439-92-1/Lead; 7439-95-4/Magnesium; 7440-66-6/Zinc; 7440-70-2/Calcium

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