Document Detail


Lead neurotoxicity: neuronal and non-neuronal cell survival in fetal and adult DRG cell cultures.
MedLine Citation:
PMID:  3714126     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the present study, neural cell cultures of fetal and adult mouse dorsal root ganglia (DRG) were prepared, exposed to various concentrations of lead (Pb) for two different schedules, and dose survival curves obtained. For the late exposure (LE) to Pb, Pb was applied from 8 DIV to 20 DIV (12 day exposure) while for the early exposure (EE), Pb was applied from 2 DIV to 20 DIV (18 day exposure). For LE there was evidence for increased vulnerability of adult compared to fetal neurons and the LD50 for both was greater than 100 microM. For both LE and EE and for both adult and fetal tissue, the non-neuronal cells were much more sensitive to the toxic Pb effects than neurons. For the LE, the adult and the fetal non-neuronal cells had LD50s of 28 microM and 58 microM respectively. For EE the LD50 for adult neurons was 35 microM. The differential effect of Pb on fetal and adult non-neuronal cells observed for LE was reversed in direction for EE; the LD50 for adult non-neuronal cells being 5.5 microM and the LD50 for fetal non-neuronal cells being only 1.7 microM, making the fetal cells about three times more sensitive than adult non-neuronal cells. An explanation of the differential effects of Pb on neurons and non-neuronal cells and on adult and fetal cells was proposed which incorporated known cell dynamics in vitro.
Authors:
B Scott; J Lew
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurotoxicology     Volume:  7     ISSN:  0161-813X     ISO Abbreviation:  Neurotoxicology     Publication Date:  1986  
Date Detail:
Created Date:  1986-07-14     Completed Date:  1986-07-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905589     Medline TA:  Neurotoxicology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  57-67     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Animals
Cell Survival
Cells, Cultured
Fetus
Ganglia, Spinal
Lead / toxicity*
Mice
Nervous System Diseases / chemically induced*
Neurons
Organometallic Compounds*
Time Factors
Chemical
Reg. No./Substance:
0/Organometallic Compounds; 301-04-2/lead acetate; 7439-92-1/Lead

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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