Document Detail

Lead intoxication in gestational and lactation periods alters the development of male reproductive organs.
MedLine Citation:
PMID:  12568462     Owner:  NLM     Status:  MEDLINE    
The effect of lead (Pb) intoxication during pregnancy and lactation on the male reproductive system was studied to evaluate the alterations caused by Pb in the development of pups. The investigations covered the effect of lead on the course of spermatogenesis and the development of the epididymis and reproductive glands. For this purpose, dams were intoxicated with 300 mg/L Pb during the gestational period and through lactation. Pups were sacrificed on Postnatal (PN) Days 12 and 21. Blood lead (PbB) and plasma iron concentrations were measured, and blood cells counted. Biochemical studies as well as histochemical analyses were performed on testes and accessory glands of the reproductive system. Lead intoxication resulted in a decrease in testis and seminal vesicle weights and an increase in DNA and RNA levels on PN Day 21. Total protein was significantly decreased by the toxicant, and alkaline and acid phosphatase levels of the gonads were reduced. Effects were also reflected in the reduction of the thickness of epithelium and of seminiferous tubule diameter (STD) as a consequence of the action of lead in the reduction in numbers of prospermatogonia and spermatocytes. Results indicate that the reproductive system targets of lead intoxication are not only the testes; lead intoxication results in the inhibition of testicular, epididymal, and seminal vesicle function, altering the biochemical composition of these organs, and consequently, affecting the normal development of germinal cells.
Isabel Corpas; M Castillo; Domingo Marquina; Maria J Benito
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ecotoxicology and environmental safety     Volume:  53     ISSN:  0147-6513     ISO Abbreviation:  Ecotoxicol. Environ. Saf.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2003-02-05     Completed Date:  2003-04-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7805381     Medline TA:  Ecotoxicol Environ Saf     Country:  United States    
Other Details:
Languages:  eng     Pagination:  259-66     Citation Subset:  IM    
Department of Animal Biology II (Animal Physiology), Faculty of Biology, Complutense University, 28040 Madrid, Spain.
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MeSH Terms
Blood Cell Count
Body Weight / drug effects
DNA / biosynthesis
Genitalia, Male / drug effects*,  metabolism,  pathology
Lead Poisoning / blood,  complications*,  physiopathology
Organ Size
Pregnancy Complications* / blood,  physiopathology
Prenatal Exposure Delayed Effects*
Prostate / drug effects,  metabolism,  pathology
RNA / biosynthesis
Seminal Vesicles / drug effects,  metabolism,  pathology
Testis / drug effects,  metabolism,  pathology
Reg. No./Substance:
63231-63-0/RNA; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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