Document Detail

Lead-induced hypertension. III. Increased hydroxyl radical production.
MedLine Citation:
PMID:  11243309     Owner:  NLM     Status:  MEDLINE    
Lead-induced hypertension has previously been shown to be closely associated with an increase in reactive oxygen species in low lead (100 ppm)-treated rats. The present study has attempted to define the specific moiety involved by noting the blood pressure (BP), reactive oxygen species (MDA-TBA), hydroxyl radical, and nitrotyrosine responses to infusion of the reactive oxygen species scavenger dimethylthiourea. Dimethylthiourea, a reputed scavenger of hydroxyl radical, normalized BP and MDA-TBA in the lead-treated rats but had no effect in normal control animals. MDA-TBA, hydroxyl radical, and nitrotyrosine, the tissue end product of peroxynitrite, were reduced to or toward normal by dimethylthiourea. The results, therefore, are consistent with the suggestion that either hydroxyl radical or peroxynitrite may be the reactive species affected by lead.
Y Ding; H C Gonick; N D Vaziri; K Liang; L Wei
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of hypertension     Volume:  14     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-03-12     Completed Date:  2001-04-19     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  169-73     Citation Subset:  IM    
Division of Nephrology and Hypertension, University of California, Irvine, USA.
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MeSH Terms
Blood Pressure / drug effects
Free Radical Scavengers / pharmacology*
Hydroxyl Radical / blood,  metabolism*
Hypertension / chemically induced*,  metabolism*,  physiopathology
Lead* / blood
Lipid Peroxides / blood
Rats, Sprague-Dawley
Thiourea / analogs & derivatives*,  pharmacology
Tyrosine / analogs & derivatives*,  blood
Reg. No./Substance:
0/Free Radical Scavengers; 0/Lipid Peroxides; 3352-57-6/Hydroxyl Radical; 3604-79-3/3-nitrotyrosine; 55520-40-6/Tyrosine; 61805-96-7/1,3-dimethylthiourea; 62-56-6/Thiourea; 7439-92-1/Lead

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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