| Lead increases aldosterone production by rat adrenal cells. | |
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MedLine Citation:
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PMID: 7721433 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Exposure to lead has been postulated to contribute to elevated blood pressure in humans and has been shown to raise blood pressure in animals. The mechanism of action of lead on blood pressure is unknown. We fed lead to rats in their drinking water and then examined the production of aldosterone by their adrenal cells in vitro. We also measured excretion of aldosterone and corticosterone by intact rats stimulated with corticotropin, with and without lead treatment. At a dose (273 ppm) that raised blood levels to 30 to 40 micrograms/dL, comparable to blood levels in exposed humans, lead induced increased aldosterone secretion in vitro and in vivo. The effect of lead was most evident when cells or animals were stimulated with aldosterone secretagogues. Experiments in vitro indicate that exposure to lead in vivo increases activity of one or more steps in the late pathway of aldosterone biosynthesis. The results suggest that the hypertensive effect of lead involves relative hyperaldosteronism and may be most evident when secretion of this hormone is stimulated. |
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Authors:
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T L Goodfriend; D L Ball; M E Elliott; C Shackleton |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Hypertension Volume: 25 ISSN: 0194-911X ISO Abbreviation: Hypertension Publication Date: 1995 Apr |
Date Detail:
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Created Date: 1995-05-25 Completed Date: 1995-05-25 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 785-9 Citation Subset: IM |
Affiliation:
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William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Glands
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cytology,
metabolism* Adrenocorticotropic Hormone / pharmacology Aldosterone / biosynthesis*, urine Angiotensin II / pharmacology Angiotensins / metabolism Animals Blood Pressure / drug effects Chromatography, High Pressure Liquid Corticosterone / urine Dose-Response Relationship, Drug Lead / pharmacology* Radioimmunoassay Rats Rats, Sprague-Dawley Weight Gain / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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DK34400/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Angiotensins; 11128-99-7/Angiotensin II; 50-22-6/Corticosterone; 52-39-1/Aldosterone; 7439-92-1/Lead; 9002-60-2/Adrenocorticotropic Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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