Document Detail

Lead Detoxification Activities of a Class of Novel DMSA-Amino Acid Conjugates.
MedLine Citation:
PMID:  21591669     Owner:  NLM     Status:  Publisher    
The coupling of the 1-carboxyl of DMSA with L-amino acids led to a class of novel 1-(carbonyl-L-amino-acid)-2,3-dimercaptosuccinic acids (DMSA-amino acid conjugates, DMSA-Gly, -Ser, -Val, -Leu, -Ile, -Asn, -Asp, -Gln, -Glu, -Met, -Phe and -Trp). In the in vivo evaluation of the Pb-loaded mice 0.4 mmol/kg of the conjugates effectively decreased the Pb levels of the femur, brain, kidney, liver and blood, greatly enhanced the urination and increased the Pb levels of both urine and feces, while caused no redistributions of Pb to the other organs, especially to the brain. In respect of lowering the bone and brain Pb DMSA-Ile, -Asn, -Gln, -Met were more effective than DMSA. This benefit was attributed to their high transmembrane ability. In contrast to Pb, the essential metals such as Fe, Cu, Zn, and Ca of the treated mice were not affected by the administration of the conjugates. Silico molecular modeling predicted that the conjugates had little hepatotoxicity, except possibly for DMSA-Phe.
Yanxia Xu; Yuji Wang; Ling Wang; Ming Zhao; Xiaoyi Zhang; Xiaomin Hu; Baoguang Hou; Li Peng; Meiqing Zheng; Jianhui Wu; Shiqi Peng
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-17
Journal Detail:
Title:  Chemical research in toxicology     Volume:  -     ISSN:  1520-5010     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807448     Medline TA:  Chem Res Toxicol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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