| Layered hydrogel of poly(γ-glutamic acid), sodium alginate, and chitosan: Fluorescence observation of structure and cytocompatibility. | |
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MedLine Citation:
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PMID: 21561745 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In this study, a novel layered hydrogel composing of poly(γ-glutamic acid) (PGA), chitosan (CS), and alginate (AL) were prepared. Furthermore, PGA, CS, and AL were labeled with different fluorescent dyes. The bilayer structure of hydrogel was then revealed using these fluorescent labeled polymers. To mimic the stability of these hydrogels in physiological fluids, the dissolution of PGA and the release of Ca(2+) from these hydrogels in normal saline were also monitored. The results showed that by adding CS to the hydrogel, the dissolution of PGA was decreased by 67%, and the release of Ca(2+) was reduced by 40%. In addition, the hydrogel exhibited no cytotoxicity for L929 fibroblasts. |
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Authors:
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Yen-Hsien Lee; Jung-Jhih Chang; Wen-Fu Lai; Ming-Chien Yang; Chiang-Ting Chien |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-9 |
Journal Detail:
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Title: Colloids and surfaces. B, Biointerfaces Volume: - ISSN: 1873-4367 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-5-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9315133 Medline TA: Colloids Surf B Biointerfaces Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier B.V. All rights reserved. |
Affiliation:
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Graduate Institute of Engineering, National Taiwan University of Science and Technology, Taipei, 106, Taiwan, ROC. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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