Document Detail

Layer - specific strain analysis: Investigation of regional deformations in a rat model of acute versus chronic myocardial infarction.
MedLine Citation:
PMID:  22777422     Owner:  NLM     Status:  Publisher    
Myocardial infarction (MI) injury extends from the endocardium towards the epicardium. This phenomenon should be taken into consideration in the detection of MI. To study the extent of damage at different stages of MI, we hypothesized that measurement of layer-specific strain will allow better delineation of the MI extent than total-wall-thickness strain, at the acute stages but not at chronic stages, when fibrosis and remodeling have already occurred. After obtaining baseline echocardiography scans, 24 rats underwent occlusion of the left anterior descending artery for 30 minutes, followed by reperfusion. Thirteen rats were re-scanned at 24 hours post-MI, and 11 rats at 2 weeks post-MI. Next, the rats were sacrificed and histological analysis for MI size was performed. The echocardiographic scans were post-processed by a layer-specific speckle tracking program to measure the Peak Circumferential Strain (S_C(Peak)) at the endocardium, middle-layer and epicardium, as well as the total-wall-thickness S_C(Peak). Linear regression for the MI size versus S_C(Peak) showed that the slope is steeper for the endocardium in comparison to the other layers (P<0.001), meaning that the endocardium is more sensitive to MI size than the other layers. Moreover, Receiver Operating Characteristics (ROC) analysis yielded better sensitivity and specificity in the detection of MI using endocardial S_C(Peak) instead of the total-wall-thickness S_C(Peak) at 24 hours post-MI (P<0.05), but not 2 weeks later. In conclusion, at the acute stages of MI, before collagen deposition, scar tissue formation and remodeling have occurred, damage may be non-transmural, and thus utilization of endocardial S_C(Peak) is advantageous over the total-wall-thickness S_C(Peak).
Noa Bachner-Hinenzon; Offir Ertracht; Assaf Malka; Marina Leitman; Zvi Vered; Ofer Binah; Dan Adam
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-9
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  -     ISSN:  1522-1539     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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