Document Detail


Layer-specific excitatory circuits differentially control recurrent network dynamics in the neocortex.
MedLine Citation:
PMID:  23313909     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the absence of external stimuli, the mammalian neocortex shows intrinsic network oscillations. These dynamics are characterized by translaminar assemblies of neurons whose activity synchronizes rhythmically in space and time. How different cortical layers influence the formation of these spontaneous cellular assemblies is poorly understood. We found that excitatory neurons in supragranular and infragranular layers have distinct roles in the regulation of intrinsic low-frequency oscillations in mice in vivo. Optogenetic activation of infragranular neurons generated network activity that resembled spontaneous events, whereas photoinhibition of these same neurons substantially attenuated slow ongoing dynamics. In contrast, light activation and inhibition of supragranular cells had modest effects on spontaneous slow activity. This study represents, to the best of our knowledge, the first causal demonstration that excitatory circuits located in distinct cortical layers differentially control spontaneous low-frequency dynamics.
Authors:
Riccardo Beltramo; Giulia D'Urso; Marco Dal Maschio; Pasqualina Farisello; Serena Bovetti; Yoanne Clovis; Glenda Lassi; Valter Tucci; Davide De Pietri Tonelli; Tommaso Fellin
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-13
Journal Detail:
Title:  Nature neuroscience     Volume:  16     ISSN:  1546-1726     ISO Abbreviation:  Nat. Neurosci.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-28     Completed Date:  2013-03-22     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  9809671     Medline TA:  Nat Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  227-34     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / physiology
Animals
Animals, Newborn
Bacterial Proteins / genetics
Electric Stimulation
Electroencephalography
Electroporation
Female
Luminescent Proteins / genetics
Mice
Mice, Inbred C57BL
Mice, Transgenic
Models, Neurological*
Neocortex / cytology*,  physiology*
Nerve Net / physiology*
Neural Pathways / physiology*
Neurons / physiology*
Nonlinear Dynamics
Patch-Clamp Techniques
Phosphopyruvate Hydratase / metabolism
Photic Stimulation
Pregnancy
Proteins / genetics
RNA, Untranslated
Retinol-Binding Proteins, Plasma / genetics
Rhodopsin / genetics
Grant Support
ID/Acronym/Agency:
GGP10138//Telethon
Chemical
Reg. No./Substance:
0/Bacterial Proteins; 0/Gt(ROSA)26Sor non-coding RNA, mouse; 0/Luminescent Proteins; 0/Proteins; 0/RNA, Untranslated; 0/Rbp4 protein, mouse; 0/Retinol-Binding Proteins, Plasma; 0/channelrhodopsin 2, mouse; 0/yellow fluorescent protein, Bacteria; 9009-81-8/Rhodopsin; EC 4.2.1.11/Phosphopyruvate Hydratase
Comments/Corrections
Comment In:
Nat Neurosci. 2013 Feb;16(2):115-7   [PMID:  23354382 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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