|Layer-specific excitatory circuits differentially control recurrent network dynamics in the neocortex.|
|PMID: 23313909 Owner: NLM Status: MEDLINE|
|In the absence of external stimuli, the mammalian neocortex shows intrinsic network oscillations. These dynamics are characterized by translaminar assemblies of neurons whose activity synchronizes rhythmically in space and time. How different cortical layers influence the formation of these spontaneous cellular assemblies is poorly understood. We found that excitatory neurons in supragranular and infragranular layers have distinct roles in the regulation of intrinsic low-frequency oscillations in mice in vivo. Optogenetic activation of infragranular neurons generated network activity that resembled spontaneous events, whereas photoinhibition of these same neurons substantially attenuated slow ongoing dynamics. In contrast, light activation and inhibition of supragranular cells had modest effects on spontaneous slow activity. This study represents, to the best of our knowledge, the first causal demonstration that excitatory circuits located in distinct cortical layers differentially control spontaneous low-frequency dynamics.|
|Riccardo Beltramo; Giulia D'Urso; Marco Dal Maschio; Pasqualina Farisello; Serena Bovetti; Yoanne Clovis; Glenda Lassi; Valter Tucci; Davide De Pietri Tonelli; Tommaso Fellin|
Related Documents :
|23646899 - Involvement of α2-antiplasmin in dendritic growth of hippocampal neurons.
23940669 - Microglial p2y12 deficiency/inhibition protects against brain ischemia.
24700609 - The map1b case: an old map that is new again.
24648009 - Involvement of irs-1 interaction with adam10 in the regulation of neurite extension.
24323419 - Fission and fusion of the neuronal endoplasmic reticulum.
24168199 - The entorhinal cortex and neurotrophin signaling in alzheimer's disease and other disor...
177789 - Vinblastine: influence on nerve conduction and synaptic transmission.
8152819 - Changes in ocular and visual variables during the menstrual cycle.
18703319 - Novelty seeking modulates medial prefrontal activity during the anticipation of emotion...
|Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't Date: 2013-01-13|
|Title: Nature neuroscience Volume: 16 ISSN: 1546-1726 ISO Abbreviation: Nat. Neurosci. Publication Date: 2013 Feb|
|Created Date: 2013-01-28 Completed Date: 2013-03-22 Revised Date: 2014-03-19|
Medline Journal Info:
|Nlm Unique ID: 9809671 Medline TA: Nat Neurosci Country: United States|
|Languages: eng Pagination: 227-34 Citation Subset: IM|
|APA/MLA Format Download EndNote Download BibTex|
Bacterial Proteins / genetics
Luminescent Proteins / genetics
Mice, Inbred C57BL
Neocortex / cytology*, physiology*
Nerve Net / physiology*
Neural Pathways / physiology*
Neurons / physiology*
Phosphopyruvate Hydratase / metabolism
Proteins / genetics
Retinol-Binding Proteins, Plasma / genetics
Rhodopsin / genetics
|0/Bacterial Proteins; 0/Gt(ROSA)26Sor non-coding RNA, mouse; 0/Luminescent Proteins; 0/Proteins; 0/RNA, Untranslated; 0/Rbp4 protein, mouse; 0/Retinol-Binding Proteins, Plasma; 0/channelrhodopsin 2, mouse; 0/yellow fluorescent protein, Bacteria; 9009-81-8/Rhodopsin; EC 18.104.22.168/Phosphopyruvate Hydratase|
|Nat Neurosci. 2013 Feb;16(2):115-7
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Lag normalization in an electrically coupled neural network.
Next Document: The organization of two new cortical interneuronal circuits.