|Layer-specific excitatory circuits differentially control recurrent network dynamics in the neocortex.|
|PMID: 23313909 Owner: NLM Status: MEDLINE|
|In the absence of external stimuli, the mammalian neocortex shows intrinsic network oscillations. These dynamics are characterized by translaminar assemblies of neurons whose activity synchronizes rhythmically in space and time. How different cortical layers influence the formation of these spontaneous cellular assemblies is poorly understood. We found that excitatory neurons in supragranular and infragranular layers have distinct roles in the regulation of intrinsic low-frequency oscillations in mice in vivo. Optogenetic activation of infragranular neurons generated network activity that resembled spontaneous events, whereas photoinhibition of these same neurons substantially attenuated slow ongoing dynamics. In contrast, light activation and inhibition of supragranular cells had modest effects on spontaneous slow activity. This study represents, to the best of our knowledge, the first causal demonstration that excitatory circuits located in distinct cortical layers differentially control spontaneous low-frequency dynamics.|
|Riccardo Beltramo; Giulia D'Urso; Marco Dal Maschio; Pasqualina Farisello; Serena Bovetti; Yoanne Clovis; Glenda Lassi; Valter Tucci; Davide De Pietri Tonelli; Tommaso Fellin|
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|Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't Date: 2013-01-13|
|Title: Nature neuroscience Volume: 16 ISSN: 1546-1726 ISO Abbreviation: Nat. Neurosci. Publication Date: 2013 Feb|
|Created Date: 2013-01-28 Completed Date: 2013-03-22 Revised Date: 2014-03-19|
Medline Journal Info:
|Nlm Unique ID: 9809671 Medline TA: Nat Neurosci Country: United States|
|Languages: eng Pagination: 227-34 Citation Subset: IM|
|APA/MLA Format Download EndNote Download BibTex|
Bacterial Proteins / genetics
Luminescent Proteins / genetics
Mice, Inbred C57BL
Neocortex / cytology*, physiology*
Nerve Net / physiology*
Neural Pathways / physiology*
Neurons / physiology*
Phosphopyruvate Hydratase / metabolism
Proteins / genetics
Retinol-Binding Proteins, Plasma / genetics
Rhodopsin / genetics
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|Nat Neurosci. 2013 Feb;16(2):115-7
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