Document Detail


Laxative potency and acute toxicity of some anthraquinone derivatives, senna extracts and fractions of senna extracts.
MedLine Citation:
PMID:  3671329     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This paper investigates the laxative effect and acute toxicity of certain fractions of senna extracts in mice. The same tests were also carried out with several pure anthraquinone derivatives common in senna pods. The results show that the laxative and toxic components of senna pods and senna extracts can be separated. The most potent laxative components, sennosides A + B and Fraction V (relative potencies 1 and 0.9 respectively), have the lowest toxicity (relative intravenous toxicities 1 and less than 1). Fractions with very low laxative activity (rhein-8-glucoside and Fraction IV, relative potencies 0.56 and 0.05) have the highest acute toxicity (relative toxicities 10 and 32 respectively).
Authors:
P Hietala; M Marvola; T Parviainen; H Lainonen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacology & toxicology     Volume:  61     ISSN:  0901-9928     ISO Abbreviation:  Pharmacol. Toxicol.     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1987-12-15     Completed Date:  1987-12-15     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8702180     Medline TA:  Pharmacol Toxicol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  153-6     Citation Subset:  IM    
Affiliation:
Extracta Ltd., Helsinki, Finland.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anthraquinones / pharmacology,  toxicity*
Cathartics* / toxicity
Female
Lethal Dose 50
Mice
Senna Extract / pharmacology,  toxicity*
Chemical
Reg. No./Substance:
0/Anthraquinones; 0/Cathartics; 8013-11-4/Senna Extract

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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