| Laxative potency and acute toxicity of some anthraquinone derivatives, senna extracts and fractions of senna extracts. | |
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MedLine Citation:
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PMID: 3671329 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This paper investigates the laxative effect and acute toxicity of certain fractions of senna extracts in mice. The same tests were also carried out with several pure anthraquinone derivatives common in senna pods. The results show that the laxative and toxic components of senna pods and senna extracts can be separated. The most potent laxative components, sennosides A + B and Fraction V (relative potencies 1 and 0.9 respectively), have the lowest toxicity (relative intravenous toxicities 1 and less than 1). Fractions with very low laxative activity (rhein-8-glucoside and Fraction IV, relative potencies 0.56 and 0.05) have the highest acute toxicity (relative toxicities 10 and 32 respectively). |
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Authors:
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P Hietala; M Marvola; T Parviainen; H Lainonen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pharmacology & toxicology Volume: 61 ISSN: 0901-9928 ISO Abbreviation: Pharmacol. Toxicol. Publication Date: 1987 Aug |
Date Detail:
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Created Date: 1987-12-15 Completed Date: 1987-12-15 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8702180 Medline TA: Pharmacol Toxicol Country: DENMARK |
Other Details:
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Languages: eng Pagination: 153-6 Citation Subset: IM |
Affiliation:
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Extracta Ltd., Helsinki, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anthraquinones / pharmacology, toxicity* Cathartics* / toxicity Female Lethal Dose 50 Mice Senna Extract / pharmacology, toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Anthraquinones; 0/Cathartics; 8013-11-4/Senna Extract |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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