Document Detail


Lauriston S. Taylor Lecture on radiation protection and measurements: what makes particle radiation so effective?
MedLine Citation:
PMID:  23032880     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The scientific basis for the physical and biological effectiveness of particle radiations has emerged from many decades of meticulous basic research. A diverse array of biologically relevant consequences at the molecular, cellular, tissue, and organism level have been reported, but what are the key processes and mechanisms that make particle radiation so effective, and what competing processes define dose dependences? Recent studies have shown that individual genotypes control radiation-regulated genes and pathways in response to radiations of varying ionization density. The fact that densely ionizing radiations can affect different gene families than sparsely ionizing radiations, and that the effects are dose- and time-dependent, has opened up new areas of future research. The complex microenvironment of the stroma and the significant contributions of the immune response have added to our understanding of tissue-specific differences across the linear energy transfer (LET) spectrum. The importance of targeted versus nontargeted effects remains a thorny but elusive and important contributor to chronic low dose radiation effects of variable LET that still needs further research. The induction of cancer is also LET-dependent, suggesting different mechanisms of action across the gradient of ionization density. The focus of this 35th Lauriston S. Taylor Lecture is to chronicle the step-by-step acquisition of experimental clues that have refined our understanding of what makes particle radiation so effective, with emphasis on the example of radiation effects on the crystalline lens of the human eye.
Authors:
Eleanor A Blakely
Publication Detail:
Type:  Lectures; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Health physics     Volume:  103     ISSN:  1538-5159     ISO Abbreviation:  Health Phys     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-03     Completed Date:  2012-12-13     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  2985093R     Medline TA:  Health Phys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  508-28     Citation Subset:  IM    
Affiliation:
Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 977, Berkeley, CA 94720, USA. eablakely@lbl.gov
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MeSH Terms
Descriptor/Qualifier:
Animals
Cataract / etiology,  metabolism,  pathology
Cell Adhesion Molecules / metabolism
Cell Communication / radiation effects
Cyclin-Dependent Kinase Inhibitor Proteins / metabolism
Elementary Particles / adverse effects*,  therapeutic use*
Environmental Exposure / adverse effects,  analysis
Epithelium / metabolism,  pathology,  radiation effects
Eye Neoplasms / radiotherapy
Humans
Lens, Crystalline / pathology,  radiation effects
Physical Processes
Radiation Dosage
Radiation Injuries / etiology,  metabolism,  pathology
Radiation Monitoring / methods*
Radiation Protection / methods*
Grant Support
ID/Acronym/Agency:
EY10737/EY/NEI NIH HHS; R01 EY010737/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Cell Adhesion Molecules; 0/Cyclin-Dependent Kinase Inhibitor Proteins
Comments/Corrections

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