| Lauriston S. Taylor Lecture on radiation protection and measurements: what makes particle radiation so effective? | |
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MedLine Citation:
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PMID: 23032880 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The scientific basis for the physical and biological effectiveness of particle radiations has emerged from many decades of meticulous basic research. A diverse array of biologically relevant consequences at the molecular, cellular, tissue, and organism level have been reported, but what are the key processes and mechanisms that make particle radiation so effective, and what competing processes define dose dependences? Recent studies have shown that individual genotypes control radiation-regulated genes and pathways in response to radiations of varying ionization density. The fact that densely ionizing radiations can affect different gene families than sparsely ionizing radiations, and that the effects are dose- and time-dependent, has opened up new areas of future research. The complex microenvironment of the stroma and the significant contributions of the immune response have added to our understanding of tissue-specific differences across the linear energy transfer (LET) spectrum. The importance of targeted versus nontargeted effects remains a thorny but elusive and important contributor to chronic low dose radiation effects of variable LET that still needs further research. The induction of cancer is also LET-dependent, suggesting different mechanisms of action across the gradient of ionization density. The focus of this 35th Lauriston S. Taylor Lecture is to chronicle the step-by-step acquisition of experimental clues that have refined our understanding of what makes particle radiation so effective, with emphasis on the example of radiation effects on the crystalline lens of the human eye. |
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Authors:
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Eleanor A Blakely |
Publication Detail:
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Type: Lectures; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Health physics Volume: 103 ISSN: 1538-5159 ISO Abbreviation: Health Phys Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-10-03 Completed Date: 2012-12-13 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 2985093R Medline TA: Health Phys Country: United States |
Other Details:
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Languages: eng Pagination: 508-28 Citation Subset: IM |
Affiliation:
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Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 977, Berkeley, CA 94720, USA. eablakely@lbl.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cataract / etiology, metabolism, pathology Cell Adhesion Molecules / metabolism Cell Communication / radiation effects Cyclin-Dependent Kinase Inhibitor Proteins / metabolism Elementary Particles / adverse effects*, therapeutic use* Environmental Exposure / adverse effects, analysis Epithelium / metabolism, pathology, radiation effects Eye Neoplasms / radiotherapy Humans Lens, Crystalline / pathology, radiation effects Physical Processes Radiation Dosage Radiation Injuries / etiology, metabolism, pathology Radiation Monitoring / methods* Radiation Protection / methods* |
| Grant Support | |
ID/Acronym/Agency:
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EY10737/EY/NEI NIH HHS; R01 EY010737/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cell Adhesion Molecules; 0/Cyclin-Dependent Kinase Inhibitor Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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