| Lauric acid and myristic acid prevent testosterone induced prostatic hyperplasia in rats. | |
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MedLine Citation:
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PMID: 19786012 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Numerous plants have proven to improve uncontrolled growth of the prostate gland and improve urinary tract symptoms associated with benign prostatic hyperplasia. Major components of those plants were lauric acid and myristic acid. Our study investigated whether lauric acid or myristic acid prevent testosterone induced prostatic hyperplasia in rats. Rats were divided into negative control and testosterone induced prostatic hyperplasia rats (positive control, low dose lauric acid treated, high dose lauric acid treated, low dose of myristic acid treated, high dose of myristic acid treated, finasteride treated). Testosterone and drug treatment were carried out for 14 days. Body weights were recorded before and after treatment. On 15th day, rats were sacrificed, prostates were weighed and histopathological studies were carried out. Lauric acid/myristic acid treatment showed significant inhibition of prostate enlargement and protection of histoarchitecture of prostate when compared with positive control group. In conclusion, the study showed that lauric acid/myristic acid reduced the increase of both prostate weight and prostate weight:body weight ratio, markers of testosterone induced prostatic hyperplasia in rats. |
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Authors:
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S V Veeresh Babu; B Veeresh; Anup A Patil; Y B Warke |
Publication Detail:
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Type: Journal Article Date: 2009-09-26 |
Journal Detail:
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Title: European journal of pharmacology Volume: 626 ISSN: 1879-0712 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-01 Completed Date: 2010-02-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 262-5 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, K.L.E.S's College of Pharmacy, J.N. Medical College Campus, Nehru Nagar, Belgum-10, Karnataka, India. veeresh_120@rediffmail.com |
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Body Weight / drug effects Lauric Acids / administration & dosage, pharmacology* Male Myristic Acid / administration & dosage, pharmacology* Organ Size / drug effects Prostate / drug effects, pathology Prostatic Hyperplasia / chemically induced*, pathology, prevention & control* Rats Rats, Wistar Testosterone / antagonists & inhibitors*, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Lauric Acids; 143-07-7/lauric acid; 544-63-8/Myristic Acid; 58-22-0/Testosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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