Document Detail

Lattice corneal dystrophy type IIIA. Clinical and histopathologic correlations.
MedLine Citation:
PMID:  2003794     Owner:  NLM     Status:  MEDLINE    
All three types of lattice corneal dystrophy are inherited and localized, and they largely involve linear corneal amyloid deposits. We encountered two white families with lattice corneal dystrophy which closely resembled type III. Four generations of one family and three of another family exhibited lattice corneal dystrophy. Because both families are from Caccamo, Sicily, Italy, we believe it is likely that both are from a single mutation. Thick, ropy lattice lines were seen to traverse the corneas almost from limbus to limbus and were easily detected with direct illumination. Histopathologic examination revealed accumulations of varying sized amyloid deposits in the stroma and ribbons of amyloid between the stroma and Bowman's layer typical of lattice corneal dystrophy type III. We have named the disease in this family lattice corneal dystrophy type IIIA, because of three differences from lattice corneal dystrophy type III: the presence of corneal erosions, the occurrence in whites, and the autosomal dominant inheritance pattern.
E L Stock; R S Feder; R B O'Grady; J Sugar; S I Roth
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  109     ISSN:  0003-9950     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-04-15     Completed Date:  1991-04-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  354-8     Citation Subset:  AIM; IM    
Cornea and External Eye Disease Laboratory, Veterans Affairs Lakeside Medical Center, Chicago, Ill.
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MeSH Terms
Aged, 80 and over
Amyloidosis / genetics,  pathology
Corneal Dystrophies, Hereditary / classification,  genetics,  pathology*
Middle Aged
Visual Acuity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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