Document Detail


Latex vascular occlusion balloons: histopathologic evaluation in a high-flow aortocaval fistula model.
MedLine Citation:
PMID:  3927675     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The treatment of carotid-cavernous fistulae with intravascular, detachable latex balloons has become an accepted method. However, the histologic changes associated with such balloon embolization in a high-flow fistula state have not been described. This study evaluated the microscopic findings in a series of 12 rats studied over a 3-month period using an aortocaval fistula model. Small latex balloons were introduced into the venae cavae of rats in whom aortocaval fistulae had been surgically created 3 weeks earlier. The histopathologic changes associated with treatment of these fistulae were examined at 1, 2, 4, 6, 8, and 12 weeks. These changes can be characterized by an acute phase with thrombus formation and acute inflammation, followed by intermediate (or subacute) and chronic phases with diminishing inflammation and progressively increasing fibrosis of the fistula site. The latex balloon became encased by the fibrotic reaction but remained nonadherent and was easily removed at every study interval. No abscess formation or persistent vasculitis was apparent, and foreign-body giant cell reaction was minimal. Closure of the high-flow fistula site required the balloon to remain inflated for at least 7-9 days.
Authors:
R G Quisling; J P Mickle; W Ballinger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  6     ISSN:  0195-6108     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:    1985 Jul-Aug
Date Detail:
Created Date:  1985-08-30     Completed Date:  1985-08-30     Revised Date:  2008-02-14    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  583-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Aorta / pathology*
Aortic Diseases / pathology*
Arteriovenous Fistula / pathology*,  therapy
Embolization, Therapeutic / instrumentation*
Foreign-Body Reaction / pathology
Inflammation / pathology
Muscle, Smooth, Vascular / pathology
Rats
Regional Blood Flow
Rubber / toxicity*
Time Factors
Venae Cavae / pathology*
Wound Healing
Chemical
Reg. No./Substance:
9006-04-6/Rubber

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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