Document Detail

Latex protein levels in external condom catheters.
MedLine Citation:
PMID:  10186971     Owner:  NLM     Status:  MEDLINE    
The Food and Drug Administration (FDA) allows for labeling medical products that have reduced levels of total water-extractable latex protein. The standard test method of the American Society for Testing and Materials (ASTM) for analysis of latex protein in natural rubber and its products is a colorimetric assay with a precipitation step called the modified Lowry assay. In an analysis of latex external condom catheters, we have documented a significant difference in protein levels between two brands of external condoms. The modified Lowry assay is a significantly less specific method than is an immunochemical assay for measuring total water-extractable latex proteins. This nonspecificity of the modified Lowry assay makes it difficult to accurately identify medical products with extremely low levels of total water-extractable latex protein.
D H Beezhold; P A Curtis; F Suber; J G Neal; W C Lara; R F Edlich
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of long-term effects of medical implants     Volume:  8     ISSN:  1050-6934     ISO Abbreviation:  J Long Term Eff Med Implants     Publication Date:  1998  
Date Detail:
Created Date:  1998-11-30     Completed Date:  1998-11-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9110830     Medline TA:  J Long Term Eff Med Implants     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  249-55     Citation Subset:  T    
Guthrie Foundation for Medical Research, Sayre, Pennsylvania 18840, USA.
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MeSH Terms
Antigens / analysis
Colorimetry / methods
Condoms* / statistics & numerical data
Immunochemistry / methods
Materials Testing / methods
Plant Proteins / analysis*
Rubber / analysis*
Urinary Catheterization / instrumentation*,  statistics & numerical data
Reg. No./Substance:
0/Antigens; 0/Plant Proteins; 9006-04-6/Rubber

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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