Document Detail


Latest in vitro and in vivo models of celiac disease.
MedLine Citation:
PMID:  23293929     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Currently, the only treatment for celiac disease is a gluten-free diet, and there is an increased desire for alternative therapies. In vitro and in vivo models of celiac disease have been generated in order to better understand the pathogenesis of celiac disease, and this review will discuss these models as well as the testing of alternative therapies using these models.
AREAS COVERED: The research discussed describes the different in vitro and in vivo models of celiac disease that currently exist and how they have contributed to our understanding of how gluten can stimulate both innate and adaptive immune responses in celiac patients. We also provide a summary on the alternative therapies that have been tested with these models and discuss whether subsequent clinical trials were done based on these tests done with these models of celiac disease.
EXPERT OPINION: Only a few of the alternative therapies that have been tested with animal models have gone on to clinical trials; however, those that did go on to clinical trial have provided promising results from a safety standpoint. Further trials are required to determine if some of these therapies may serve as an effective adjunct to a gluten-free diet to alleviate the adverse affects associated with accidental gluten exposure. A "magic-bullet" approach may not be the answer to celiac disease, but possibly a future cocktail of these different therapeutics may allow celiac patients to consume an unrestricted diet.
Authors:
Samantha Stoven; Joseph A Murray; Eric V Marietta
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-08
Journal Detail:
Title:  Expert opinion on drug discovery     Volume:  8     ISSN:  1746-045X     ISO Abbreviation:  Expert Opin Drug Discov     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-20     Completed Date:  2013-08-13     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  101295755     Medline TA:  Expert Opin Drug Discov     Country:  England    
Other Details:
Languages:  eng     Pagination:  445-57     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adaptive Immunity
Animals
Celiac Disease / diet therapy*,  immunology
Clinical Trials as Topic
Diet, Gluten-Free / methods
Disease Models, Animal*
Glutens / adverse effects
Humans
Immunity, Innate
Models, Theoretical
Grant Support
ID/Acronym/Agency:
DK071003/DK/NIDDK NIH HHS; DK57892/DK/NIDDK NIH HHS; R01 DK057892/DK/NIDDK NIH HHS; R01 DK071003/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
8002-80-0/Glutens
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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