Document Detail


Lateralized cerebellar contributions to word generation: a phonemic and semantic fluency study.
MedLine Citation:
PMID:  20714059     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Impairment on verbal fluency tasks has been one of the more consistently reported neuropsychological findings after cerebellar lesions, but it has not been uniformly observed and the possible underlying cognitive basis has not been investigated. We tested twenty-two patients with chronic, unilateral cerebellar lesions (12 Left, 10 Right) and thirty controls on phonemic and semantic fluency tasks. We measured total words produced, words produced in the initial 15 seconds, errors and strategy switches. In the phonemic fluency task, the right cerebellar lesion (RC) group produced significantly fewer words compared to the left cerebellar lesion (LC) group and healthy controls, particularly over the first 15 seconds of the task with no increase in errors and significantly fewer switches over the entire task. In the semantic fluency task there was only a modest decrease in total words in the RC group compared to controls. RC lesions impair fluency with many of the same performance characteristics as left prefrontal lesions. This supports the hypotheses of a prefrontal-lateral cerebellar system for modulation of attention/executive or strategy demanding tasks.
Authors:
Tom A Schweizer; Michael P Alexander; B A Susan Gillingham; Michael Cusimano; Donald T Stuss
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Behavioural neurology     Volume:  23     ISSN:  1875-8584     ISO Abbreviation:  Behav Neurol     Publication Date:  2010  
Date Detail:
Created Date:  2010-08-17     Completed Date:  2010-12-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8914585     Medline TA:  Behav Neurol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  31-7     Citation Subset:  IM    
Affiliation:
Division of Neurosurgery, St. Michael's Hospital, 30 Bond Street, Toronto, Ontario, Canada. schweizert@smh.toronto.on.ca
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Brain Hemorrhage, Traumatic / physiopathology,  psychology
Cerebellar Diseases / physiopathology,  psychology
Cerebellar Neoplasms / surgery
Cerebellum / physiology*
Executive Function / physiology
Female
Functional Laterality / physiology*
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Middle Aged
Neuropsychological Tests
Phonetics
Semantics
Speech / physiology*
Stroke / complications
Verbal Behavior / physiology*
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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