Document Detail


Lateralization of temporal lobe epilepsy using resting functional magnetic resonance imaging connectivity of hippocampal networks.
MedLine Citation:
PMID:  22779926     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Early surgical intervention can be advantageous in the treatment of refractory temporal lobe epilepsy (TLE). The success of TLE surgery relies on accurate lateralization of the seizure onset. The purpose of this study was to determine whether resting functional MRI (fMRI) connectivity mapping of the hippocampus has the potential to complement conventional presurgical evaluations in distinguishing left from right TLE. In addition, we sought to determine whether this same network might separate patients with favorable from unfavorable postoperative outcomes.
METHODS: Resting fMRI acquisitions were performed on 21 patients with TLE and 15 healthy controls. The patients included seven patients with left TLE and seven patients with right TLE with seizure-free postoperative outcome, and five patients with left TLE and two patients with right TLE with recurring seizures after surgery. Functional connectivity maps to each hippocampus were determined for each subject and were compared between the controls and the seizure-free patients with left TLE and with right TLE. The one network identified was then quantified in the patients with TLE and recurring seizures.
KEY FINDINGS: The resting functional connectivity between the right hippocampus and the ventral lateral nucleus of the right thalamus was the most statistically significant network to distinguish between seizure-free patients with left TLE and with right TLE with high sensitivity and specificity. This connectivity was also significantly greater in the seizure-free patients with left TLE than the healthy controls. Finally, six of the seven patients in whom seizures recurred after surgery had connectivity values in this network unlike those who were seizure-free.
SIGNIFICANCE: This study identified a region in the ventral lateral nucleus of the right thalamus whose connectivity to the hippocampi separates left from right TLE subjects. This suggests that the quantification of resting-state functional magnetic resonance imaging (MRI) connectivity across this network may be a potential indicator of lateralization of TLE that may be added to other presurgical MRI assessments. Further validation in a larger, independent cohort is required.
Authors:
Victoria L Morgan; Hasan H Sonmezturk; John C Gore; Bassel Abou-Khalil
Related Documents :
23278646 - Hla-drb1 and hla-dqb1 genes and allergic broncopulmonary aspergillosis susceptibility a...
8184646 - Incidence of thyroid carcinoma in a common surgical practice: the problems.
17466006 - Efficacy and safety of orbital decompression in treatment of thyroid-associated ophthal...
15212646 - Diagnostic value of serum thyroglobulin measurements in the follow-up of differentiated...
10704676 - Interphase detection of t(4;14)(p16.3;q32.3) by in situ hybridization and fgfr3 overexp...
2730796 - Changes in pharmacologic treatment of hyperlipidemia.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-07-10
Journal Detail:
Title:  Epilepsia     Volume:  53     ISSN:  1528-1167     ISO Abbreviation:  Epilepsia     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-07     Completed Date:  2012-11-16     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1628-35     Citation Subset:  IM    
Copyright Information:
Wiley Periodicals, Inc. © 2012 International League Against Epilepsy.
Affiliation:
Vanderbilt University Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee, USA. victoria.morgan@vanderbilt.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Cohort Studies
Epilepsy, Temporal Lobe / diagnosis,  physiopathology*
Female
Hippocampus / physiology*
Humans
Magnetic Resonance Imaging* / methods
Male
Middle Aged
Nerve Net / physiology*
Neural Pathways / physiology
Rest / physiology*
Thalamus / physiology
Young Adult
Grant Support
ID/Acronym/Agency:
KL2 RR024977/RR/NCRR NIH HHS; KL2 TR000446/TR/NCATS NIH HHS; R01 NS055822/NS/NINDS NIH HHS; R01 NS055822/NS/NINDS NIH HHS; TL1 RR024978/RR/NCRR NIH HHS; TL1 TR000447/TR/NCATS NIH HHS; UL1 RR024975/RR/NCRR NIH HHS; UL1 RR024975-01/RR/NCRR NIH HHS; UL1 TR000445/TR/NCATS NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Variation in Peak Growing Season Net Ecosystem Production Across the Canadian Arctic.
Next Document:  Variation of radiation-sensitivity of neural stem and progenitor cell populations within the develop...