| Lateralisation of sound in temporal-lobe epilepsy: Comparison between pre- and postoperative performances and ERPs. | |
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MedLine Citation:
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PMID: 22883476 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: Our aim was to investigate if spatial hearing is impaired in mesial temporal lobe epilepsy and temporal lobectomy has an effect on this function. METHODS: Thirteen patients with mesial temporal lobe epilepsy (TLE) due to sclerosis in their left (n=6) or right (n=7) hippocampus were studied. Their sound lateralisation performance indexed by d' was tested against that of a group of normal subjects (n=13). Patients' ERPs to lateralisation shifts induced by interaural disparities of intensity (IID) and time (ITD) were also recorded. Eight of the patients were re-tested after they underwent anterior temporal lobectomy, which involved the resection/removal of medial structures including amygdala, hippocampus and parahippocampal gyrus. RESULTS: The sound-lateralisation performance of the TLE patients was significantly lower than normal subjects, and this disadvantage of the patients was specific to IID-based lateralisation. Amplitudes of their N1 and P2 responses to laterally shifting sounds were much lower than those reported previously for normal subjects. Lobectomy did not have a statistically significant effect on patients' sound-lateralisation performance nor on the amplitude of their auditory directional ERPs. CONCLUSIONS: The results show that especially the IID-based sound-lateralisation performance is impaired in TLE patients and that lobectomy should not cause any further deterioration. SIGNIFICANCE: This study suggests that a test for assessing the ability of sound lateralisation based on each of the IID and ITD cues should be included in the evaluation of TLE patients. |
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Authors:
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F Irsel Tezer; Barkin Ilhan; Nurhan Erbil; Serap Saygi; Nejat Akalan; Pekcan Ungan |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-7 |
Journal Detail:
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Title: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology Volume: - ISSN: 1872-8952 ISO Abbreviation: Clin Neurophysiol Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883319 Medline TA: Clin Neurophysiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Hacettepe University, Faculty of Medicine, Department of Neurology, Ankara, Turkey. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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