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Lateral ventricles in aneuploidies at 11-13 weeks' gestation.
MedLine Citation:
PMID:  22605664     Owner:  NLM     Status:  Publisher    
Objective: To examine the possible association between aneuploidies and lateral cerebral ventriculomegaly in the first trimester of pregnancy. Methods: Three dimensional brain volumes were acquired by transvaginal ultrasound at 11-13 weeks' gestation from 410 euploid fetuses and in 63 cases of trisomy 21, 34 of trisomy 18 and 7 of trisomy 13. The lateral ventricles were assessed in a transverse view, just above the roof of the third ventricle and measurements were obtained of the area of the lateral ventricles and area of the choroid plexuses. The ratio between choroid plexus and lateral ventricle areas (CLR) was calculated. The measurements in the aneuploid fetuses were compared to those in euploid fetuses. Results: In euploid fetuses the area of the lateral ventricles and choroid plexuses increased, whereas the CLR decreased with fetal biparietal diameter (BPD). In fetuses with trisomy 21 lateral ventricle area and choroid plexus area were smaller but CLR was nor significantly different from euploid fetuses. In trisomy 18 and 13 CLR was significantly smaller than in euploid fetuses. The CLR was below the 5(th) percentile of the normal range in 11 (32.4%) fetuses with trisomy 18 and in 6 (85.7%) with trisomy 13. Conclusions: At 11-13 weeks' gestation most fetuses with trisomy 13 and one third of fetuses with trisomy 18 have evidence of ventriculomegaly. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
Teresa Loureiro; Fred Ushakov; Nerea Maiz; Nuno Montenegro; Kypros H Nicolaides
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-17
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  -     ISSN:  1469-0705     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
Department of Obstetrics and Gynecology, S. João Hospital, Medical School, University of Porto, Porto, Portugal; Fetal Medicine Unit, University College Hospital, London, UK.
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