Document Detail

Lateral pressure profiles in cholesterol-DPPC bilayers.
MedLine Citation:
PMID:  16205919     Owner:  NLM     Status:  MEDLINE    
By means of atomistic molecular dynamics simulations, we study cholesterol-DPPC (dipalmitoyl phosphatidylcholine) bilayers of different composition, from pure DPPC bilayers to a 1:1 mixture of DPPC and cholesterol. The lateral pressure profiles through the bilayers are computed and separated into contributions from the different components. We find that the pressure inside the bilayer changes qualitatively for cholesterol concentrations of about 20% or higher. The pressure profile in the inside of the bilayer then turns from a rather flat shape into an alternating sequence of regions with large positive and negative lateral pressure. The changes in the lateral pressure profile are so characteristic that specific interaction between cholesterol and molecules such as membrane proteins mediated solely via the lateral pressure profile might become possible.
Michael Patra
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-10-05
Journal Detail:
Title:  European biophysics journal : EBJ     Volume:  35     ISSN:  0175-7571     ISO Abbreviation:  Eur. Biophys. J.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-05     Completed Date:  2006-08-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8409413     Medline TA:  Eur Biophys J     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  79-88     Citation Subset:  IM    
Biophysics and Statistical Mechanics Group, Laboratory of Computational Engineering, Helsinki University of Technology, P. O. Box 9203, 02015 HUT, Finland.
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MeSH Terms
1,2-Dipalmitoylphosphatidylcholine / chemistry*
Cholesterol / chemistry*
Ion Channels / metabolism
Lipid Bilayers / chemistry*
Molecular Conformation
Stress, Mechanical
Surface Properties
Reg. No./Substance:
0/Ion Channels; 0/Lipid Bilayers; 2644-64-6/1,2-Dipalmitoylphosphatidylcholine; 57-88-5/Cholesterol

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