| Lateral hypothalamic stimulation-produced analgesia: inferred refractory period of directly stimulated neurons and resistance to pimozide antagonism. | |
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MedLine Citation:
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PMID: 3432389 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Electrical stimulation in lateral hypothalamic sites (ESLH) supporting appetitive behavior and reward also diminishes pain and aversion responses that are organized high in the neuraxis. A paired-pulse stimulation technique was used, in two different behavioral paradigms, to infer the absolute refractory periods of LH neurons that mediate this apparent supraspinal analgesia. In both paradigms, recovery from refractoriness--reflected by increased analgesic action--was evident at intrapair intervals of 0.8 msec and greater. This finding suggests that the overlap, if any, between first stage neurons mediating analgesia and appetitive/reward behavior may be restricted to the 'heterogeneous slow population' distinguished by Gratton and Wise. The dopamine antagonist pimozide, at doses known to diminish ESLH-induced feeding and reward (0.25 and 0.5 mg/kg), failed to affect analgesia. Thus, the dopaminergic second stage neurons deemed critical to feeding and reward may not play an important role in analgesia. Finally, ESLH-induced ameliorative action as a case of 'aversion-gating' or a dimension of classical somatosensory analgesia is discussed. |
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Authors:
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K D Carr; T H Bak |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Physiology & behavior Volume: 41 ISSN: 0031-9384 ISO Abbreviation: Physiol. Behav. Publication Date: 1987 |
Date Detail:
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Created Date: 1988-03-15 Completed Date: 1988-03-15 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 371-8 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, Millhauser Laboratories, New York University Medical Center, NY 10016. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analgesia* Animals Appetitive Behavior / drug effects, physiology Electric Stimulation Hypothalamus / drug effects, physiology* Male Neural Conduction* Neurons / physiology Pimozide / pharmacology* Rats Rats, Inbred Strains Refractory Period, Electrophysiological* Reward |
| Grant Support | |
ID/Acronym/Agency:
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DA 03956/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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2062-78-4/Pimozide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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