Document Detail


Lateral hypothalamic involvement in feeding elicited from the ventral pallidum.
MedLine Citation:
PMID:  23190138     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intense feeding can be elicited by injections of the GABA(A) receptor antagonist bicuculline into the medial ventral pallidum (VPm), a basal forebrain structure anatomically interposed between two other feeding-related brain regions, the nucleus accumbens shell and the lateral hypothalamus (LH). To determine whether the VPm effects changes in feeding behavior through actions on the LH, we examined feeding following unilateral injections of bicuculline into the VPm made either ipsilateral or contralateral to a unilateral excitotoxic lesion of the LH in nondeprived rats. We found that lesions of the LH significantly attenuated feeding induced from the ipsilateral VPm, as compared to sham-operated controls. In striking contrast, unilateral LH lesions significantly potentiated the feeding response elicited by injections of bicuculline into the contralateral VPm. The 'ipsilateral-contralateral disruption' design we used makes it extremely unlikely that our findings could have resulted from nonspecific effects of the lesions. These results suggest that the LH is causally involved in mediating the ingestive effects produced by activation of the VPm, and provide an important insight into the functional circuitry by which basal forebrain structures control food intake in mammals.
Authors:
Thomas R Stratford; David Wirtshafter
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-11-29
Journal Detail:
Title:  The European journal of neuroscience     Volume:  37     ISSN:  1460-9568     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-18     Completed Date:  2013-11-04     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  France    
Other Details:
Languages:  eng     Pagination:  648-53     Citation Subset:  IM    
Copyright Information:
© 2012 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.
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MeSH Terms
Descriptor/Qualifier:
Animals
Appetite Regulation / physiology*
Feeding Behavior / physiology*
Functional Laterality / physiology
Hypothalamus / physiology*
Immunohistochemistry
Male
Neural Pathways / physiology*
Prosencephalon / physiology*
Rats
Rats, Sprague-Dawley
Grant Support
ID/Acronym/Agency:
R01 DK071738/DK/NIDDK NIH HHS; R01DK071738/DK/NIDDK NIH HHS; R03DA020802/DA/NIDA NIH HHS
Comments/Corrections

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