Document Detail


Lateral cortical impact injury in rats: cerebrovascular effects of varying depth of cortical deformation and impact velocity.
MedLine Citation:
PMID:  7861449     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intracranial pressure (ICP), blood pressure (BP), cerebral perfusion pressure (CPP), and cortical perfusion (LDF) of the contralateral parietal cortex were measured after cortical impact injury in 36 rats. Changes in these physiologic parameters were compared using analysis of variance to a group of 11 rats who received a sham impact. In one series of experiments, the velocity and duration of the impact injury were kept constant, and the severity of the injury was determined by varying the depth of cortical deformation from 2 to 3 mm. The peak pressure inside the skull was directly related to the depth of cortical deformation, and was 93 +/- 16, 182 +/- 18, and 268 +/- 57 mm Hg with the 2, 2.5, and 3 mm deformation, respectively, when the impact velocity was 5 m/sec. With the 2 mm depth injury, there was a transient decrease in BP (p < 0.05) and a 12% decrease in LDF after the impact. With the 2.5 mm depth injury, a small transient increase in ICP and decrease in BP and a 30% decrease in LDF occurred (p < 0.05). ICP then gradually increased throughout the 8 h experiment, becoming significantly greater than the sham-injured animals by 5 h after the impact. LDF gradually returned toward normal throughout the experiment. With the 3 mm depth injury, a marked transient increase in ICP (p < 0.05) and BP (p < 0.05) occurred immediately after the impact. The increase in BP lasted < 5 min, and subsequently the BP decreased to approximately 50 mm Hg for the rest of the experiment. The initial marked increase in ICP lasted 15 min and then remained 5-10 mm Hg higher (p < 0.05) than in the sham-injured animals for the rest of the experiment. LDF decreased by an average of 50% (p < 0.05) immediately after the impact and remained lower than that of the sham-injured animals for the rest of the experiment. In another series of experiments, the depth of cortical deformation was kept constant at 2.5 mm, and the severity of the injury was determined by varying the velocity from 1 to 5 m/sec. The peak ICP was significantly related to the impact velocity, averaging 45 +/- 12, 66 +/- 9, and 182 +/- 18 mm Hg with the 1, 3, and 5 m/sec impact injuries, respectively. The 1 m/sec impact had no effect on ICP and only a transient decrease in BP.(ABSTRACT TRUNCATED AT 400 WORDS)
Authors:
L Cherian; C S Robertson; C F Contant; R M Bryan
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neurotrauma     Volume:  11     ISSN:  0897-7151     ISO Abbreviation:  J. Neurotrauma     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1995-03-21     Completed Date:  1995-03-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8811626     Medline TA:  J Neurotrauma     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  573-85     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Baylor College of Medicine, Houston, Texas.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Blood Pressure
Brain Injuries / pathology,  physiopathology*
Cerebral Cortex / blood supply,  injuries*,  pathology
Cerebrovascular Circulation*
Hemodynamics
Intracranial Pressure
Rats
Grant Support
ID/Acronym/Agency:
P01-NS27616/NS/NINDS NIH HHS; R01-HLB41960/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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