Document Detail


Latent tuberculosis infection and active tuberculosis in patients with psoriasis: a study on the incidence of tuberculosis and the prevalence of latent tuberculosis disease in patients with moderate-severe psoriasis in Spain.BIOBADADERM registry.
MedLine Citation:
PMID:  23134268     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Introduction  The incidence of tuberculosis (TB) or the prevalence of latent tuberculosis infection (LTBI) in psoriasis patients has not been described in the Spanish population. We carried out a study with the objectives: (i) To describe the incidence of TB in patients with psoriasis on systemic treatment in the Spanish population; (ii) To determine the prevalence of LTBI in patients who are candidates for biological treatment; and (iii) To investigate the level of compliance with current recommendations for LTBI and TB screening. Methods  Data were obtained from BIOBADADERM (Spanish registry for systemic biological and non-biological treatments in psoriasis). An analysis was performed of the exposed cohort to determine the prevalence of LTBI and to describe compliance with the screening guidelines. Results  A total of 1425 patients were registered in BIOBADADERM. They included 793 (56%) patients exposed to biological treatment and 632 (44%) treated with conventional systemic drug. Overall follow-up was 3720 person-years. Of the 793, 20.5% (163) were diagnosed with LTBI before starting biological treatment. The rate of active TB for the exposed cohort was 145 cases × 100 000 patient-years (95% CI 54-389). No case of TB was found in the control group. Screening for LTBI was performed in 83% of the exposed sample. Conclusion  Patients with psoriasis who are exposed to biological treatment appear to be at greater risk for tuberculosis. In Spain, up to 20% of patients with psoriasis who are candidates for biological therapy have LTBI. There continues to be a significant percentage of errors in compliance with clinical guidelines.
Authors:
A I Sánchez-Moya; I García-Doval; G Carretero; J Sánchez-Carazo; C Ferrandiz; E Herrera Ceballos; M Alsina; M Ferrán; J-L López-Estebaranz; F Gómez-García; P De la Cueva Dobao; J-M Carrascosa; F Vanaclocha; I Belinchón; F Peral; E Dauden;
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-8
Journal Detail:
Title:  Journal of the European Academy of Dermatology and Venereology : JEADV     Volume:  -     ISSN:  1468-3083     ISO Abbreviation:  J Eur Acad Dermatol Venereol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9216037     Medline TA:  J Eur Acad Dermatol Venereol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. Journal of the European Academy of Dermatology and Venereology © 2012 European Academy of Dermatology and Venereology.
Affiliation:
Hospital Universitario la Princesa, Madrid Unidad de investigación Fundación AEDV, Madrid Hospital Universitario de Gran Canaria Dr Negrín, Las Palmas de Gran Canaria Hospital General Universitario de Valencia, Valencia Hospital Universitario Germans Trias i Pujol, Badalona Hospital Universitario Virgen de la Victoria, Málaga Hospital Clinic de Barcelona, Barcelona Hospital del Mar, Parc de Salut Mar, Barcelona Fundación Hospital Alcorcon, Madrid Hospital Universitario Reina Sofía, Cordoba Hospital Infanta Leonor, Madrid Hospital Universitario Germans Trias i Pujol, Badalona Hospital Universitario 12 de Octubre, Madrid Hospital General Universitario de Alicante, Alicante Hospital Universitario Virgen de la Macarena, Sevilla Hospital Universitario la Princesa, Madrid, Spain.
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