Document Detail

Latent hypoparathyroidism in an osteoporotic patient with multiple endocrinopathies and secondary hemochromatosis due to multiple blood transfusions, unmasked by alendronate and glucocorticoid at adrenal crisis.
MedLine Citation:
PMID:  18344638     Owner:  NLM     Status:  MEDLINE    
A 30-year-old normocalcemic man with hypopituitarism, hypogonadism, diabetes mellitus, and secondary hemochromatosis due to multiple blood transfusions was admitted because of adrenal crisis. After intravenous administration of saline and cortisol, the corrected serum level of calcium decreased to 7.3 mg/dl. This osteoporotic patient had been prescribed alendronate for radial bone fracture. Since the increase in intact PTH (68 pg/ml) was impaired compared to that seen in hypocalcemic patients with secondary hyperparathyroidism, we presume that the patient has had latent hypoparathyroidism, which was unmasked by the administration of glucocorticoid and bisphosphonate. With a supplemented dose of 1alpha-OHD3, the patient has been eucalcemic.
Keiji Tanimoto; Yumiko Okubo; Chie Harada; Hiroshi Saito; Akira Sata; Aiko Nishikawa; Rina Ohwada; Mika Tsuiki; Masaaki Yamamoto; Etsuko Hashimoto; Kanji Sato; Kazue Takano
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2008-03-17
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  47     ISSN:  1349-7235     ISO Abbreviation:  Intern. Med.     Publication Date:  2008  
Date Detail:
Created Date:  2008-03-17     Completed Date:  2008-04-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  515-20     Citation Subset:  IM    
Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women's Medical University.
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MeSH Terms
Adrenal Glands / metabolism
Alendronate / therapeutic use*
Blood Transfusion / adverse effects*
Bone Density Conservation Agents / therapeutic use
Bone Resorption / drug therapy
Calcium / blood
Diabetes Mellitus / metabolism
Endocrine System Diseases / metabolism*
Glucocorticoids / therapeutic use*
Hemochromatosis / diagnosis*,  etiology
Hypogonadism / metabolism
Hypoparathyroidism / diagnosis*,  metabolism
Hypopituitarism / metabolism
Osteoporosis / drug therapy*,  metabolism
Parathyroid Hormone / blood
Reg. No./Substance:
0/Bone Density Conservation Agents; 0/Glucocorticoids; 0/Parathyroid Hormone; 66376-36-1/Alendronate; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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